Oligodendrogenesis after Cerebral Ischemia

Oligodendrogenesis after Cerebral Ischemia

AbstractNeural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models...

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Bibliographic Details
Main Authors: Ruilan eZhang, Michael eChopp, Zheng Gang eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
MicroRNAs
Neural Stem Cells
cerebral ischemia
oligodendrocytes
oligodendrocyte progenitor cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00201/full
Description
Summary:AbstractNeural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that cerebral ischemia induces oligodendrogenesis during brain repair processes. This article will review evidence of stroke-induced proliferation and differentiation of OPCs that are either resident in white matter or are derived from SVZ neural progenitor cells and of therapies that amplify endogenous oligodendrogenesis in ischemic brain.
ISSN:1662-5102

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