Oligodendrogenesis after Cerebral Ischemia
AbstractNeural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models...
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2013-10-01
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00201/full |
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doaj-30906dfa82764551830582bc1944d1e12020-11-24T21:04:10ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-10-01710.3389/fncel.2013.0020165272Oligodendrogenesis after Cerebral IschemiaRuilan eZhang0Michael eChopp1Michael eChopp2Zheng Gang eZhang3Henry Ford Hospital, Detroit, MichiganHenry Ford Hospital, Detroit, MichiganOakland UniversityHenry Ford Hospital, Detroit, MichiganAbstractNeural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that cerebral ischemia induces oligodendrogenesis during brain repair processes. This article will review evidence of stroke-induced proliferation and differentiation of OPCs that are either resident in white matter or are derived from SVZ neural progenitor cells and of therapies that amplify endogenous oligodendrogenesis in ischemic brain.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00201/fullMicroRNAsNeural Stem Cellscerebral ischemiaoligodendrocytesoligodendrocyte progenitor cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruilan eZhang Michael eChopp Michael eChopp Zheng Gang eZhang |
spellingShingle |
Ruilan eZhang Michael eChopp Michael eChopp Zheng Gang eZhang Oligodendrogenesis after Cerebral Ischemia Frontiers in Cellular Neuroscience MicroRNAs Neural Stem Cells cerebral ischemia oligodendrocytes oligodendrocyte progenitor cells |
author_facet |
Ruilan eZhang Michael eChopp Michael eChopp Zheng Gang eZhang |
author_sort |
Ruilan eZhang |
title |
Oligodendrogenesis after Cerebral Ischemia |
title_short |
Oligodendrogenesis after Cerebral Ischemia |
title_full |
Oligodendrogenesis after Cerebral Ischemia |
title_fullStr |
Oligodendrogenesis after Cerebral Ischemia |
title_full_unstemmed |
Oligodendrogenesis after Cerebral Ischemia |
title_sort |
oligodendrogenesis after cerebral ischemia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular Neuroscience |
issn |
1662-5102 |
publishDate |
2013-10-01 |
description |
AbstractNeural stem cells in the subventricular zone (SVZ) of the lateral ventricle of adult rodent brain generate oligodendrocyte progenitor cells (OPCs) that disperse throughout the corpus callosum and striatum where some of OPCs differentiate into mature oligodendrocytes. Studies in animal models of stroke demonstrate that cerebral ischemia induces oligodendrogenesis during brain repair processes. This article will review evidence of stroke-induced proliferation and differentiation of OPCs that are either resident in white matter or are derived from SVZ neural progenitor cells and of therapies that amplify endogenous oligodendrogenesis in ischemic brain. |
topic |
MicroRNAs Neural Stem Cells cerebral ischemia oligodendrocytes oligodendrocyte progenitor cells |
url |
http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00201/full |
work_keys_str_mv |
AT ruilanezhang oligodendrogenesisaftercerebralischemia AT michaelechopp oligodendrogenesisaftercerebralischemia AT michaelechopp oligodendrogenesisaftercerebralischemia AT zhenggangezhang oligodendrogenesisaftercerebralischemia |
_version_ |
1716771733599420416 |