Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore
Singapore experienced a large epidemic of hand, foot and mouth disease (HFMD) in 2000. After reviewing HFMD notifications from doctors and child-care centers, we found that the incidence of HFMD rose in September and declined at the end of October. During this period, 3,790 cases were reported. We p...
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doaj-3097779571d040a58f4df71c8371b3e12020-11-24T22:16:01ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592003-01-0191788510.3201/eid0901.020112Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, SingaporeKwai Peng ChanKee Tai GohChia Yin ChongEng Swee TeoGilbert LauAi Ee LingSingapore experienced a large epidemic of hand, foot and mouth disease (HFMD) in 2000. After reviewing HFMD notifications from doctors and child-care centers, we found that the incidence of HFMD rose in September and declined at the end of October. During this period, 3,790 cases were reported. We performed enteroviral cultures on 311 and 157 specimens from 175 HFMD patients and 107 non-HFMD patients, respectively; human enterovirus 71 (HEV71) was the most frequently isolated virus from both groups. Most of the HFMD patients were <4 years of age. Three HFMD and two non-HFMD patients died. Specimens from two HFMD and both non-HFMD patients were culture positive for HEV71; a third patient was possibly associated with the virus. Autopsies performed on all three HFMD and one of the non-HFMD case-patients showed encephalitis, interstitial pneumonitis, and myocarditis. A preparedness plan for severe HFMD outbreaks provided for the prompt, coordinated actions needed to control the epidemic.https://wwwnc.cdc.gov/eid/article/9/1/02-0112_articlehandfoot and mouth diseasehuman enterovirus infectionHEV71encephalitismyocarditis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kwai Peng Chan Kee Tai Goh Chia Yin Chong Eng Swee Teo Gilbert Lau Ai Ee Ling |
spellingShingle |
Kwai Peng Chan Kee Tai Goh Chia Yin Chong Eng Swee Teo Gilbert Lau Ai Ee Ling Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore Emerging Infectious Diseases hand foot and mouth disease human enterovirus infection HEV71 encephalitis myocarditis |
author_facet |
Kwai Peng Chan Kee Tai Goh Chia Yin Chong Eng Swee Teo Gilbert Lau Ai Ee Ling |
author_sort |
Kwai Peng Chan |
title |
Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore |
title_short |
Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore |
title_full |
Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore |
title_fullStr |
Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore |
title_full_unstemmed |
Epidemic Hand, Foot and Mouth Disease Caused by Human Enterovirus 71, Singapore |
title_sort |
epidemic hand, foot and mouth disease caused by human enterovirus 71, singapore |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2003-01-01 |
description |
Singapore experienced a large epidemic of hand, foot and mouth disease (HFMD) in 2000. After reviewing HFMD notifications from doctors and child-care centers, we found that the incidence of HFMD rose in September and declined at the end of October. During this period, 3,790 cases were reported. We performed enteroviral cultures on 311 and 157 specimens from 175 HFMD patients and 107 non-HFMD patients, respectively; human enterovirus 71 (HEV71) was the most frequently isolated virus from both groups. Most of the HFMD patients were <4 years of age. Three HFMD and two non-HFMD patients died. Specimens from two HFMD and both non-HFMD patients were culture positive for HEV71; a third patient was possibly associated with the virus. Autopsies performed on all three HFMD and one of the non-HFMD case-patients showed encephalitis, interstitial pneumonitis, and myocarditis. A preparedness plan for severe HFMD outbreaks provided for the prompt, coordinated actions needed to control the epidemic. |
topic |
hand foot and mouth disease human enterovirus infection HEV71 encephalitis myocarditis |
url |
https://wwwnc.cdc.gov/eid/article/9/1/02-0112_article |
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