Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome
The causes of luteal phase progesterone deficiency in polycystic ovary syndrome (PCOS) are not known. To determine the possible involvement of hyperinsulinemia in luteal phase progesterone deficiency in women with PCOS, we examined the relationship between progesterone, luteinizing hormone (LH) and...
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Associação Brasileira de Divulgação Científica
2004-01-01
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100007 |
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doaj-309857a9e52d405d96af499d004c5e5b2020-11-25T01:19:19ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73102004-01-01371116371644Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndromeMeenakumari K.J.Agarwal S.Krishna A.Pandey L.K.The causes of luteal phase progesterone deficiency in polycystic ovary syndrome (PCOS) are not known. To determine the possible involvement of hyperinsulinemia in luteal phase progesterone deficiency in women with PCOS, we examined the relationship between progesterone, luteinizing hormone (LH) and insulin during the luteal phase and studied the effect of metformin on luteal progesterone levels in PCOS. Patients with PCOS (19 women aged 18-35 years) were treated with metformin (500 mg three times daily) for 4 weeks prior to the test cycle and throughout the study period, and submitted to ovulation induction with clomiphene citrate. Blood samples were collected from control (N = 5, same age range as PCOS women) and PCOS women during the late follicular (one sample) and luteal (3 samples) phases and LH, insulin and progesterone concentrations were determined. Results were analyzed by one-way analysis of variance (ANOVA), Duncan's test and Karl Pearson's coefficient of correlation (r). The endocrine study showed low progesterone level (4.9 ng/ml) during luteal phase in the PCOS women as compared with control (21.6 ng/ml). A significant negative correlation was observed between insulin and progesterone (r = -0.60; P < 0.01) and between progesterone and LH (r = -0.56; P < 0.05) concentrations, and a positive correlation (r = 0.83; P < 0.001) was observed between LH and insulin. The study further demonstrated a significant enhancement in luteal progesterone concentration (16.97 ng/ml) in PCOS women treated with metformin. The results suggest that hyperinsulinemia/insulin resistance may be responsible for low progesterone levels during the luteal phase in PCOS. The luteal progesterone level may be enhanced in PCOS by decreasing insulin secretion with metformin.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100007Polycystic ovary syndromeMetforminLuteal phase defectProgesterone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meenakumari K.J. Agarwal S. Krishna A. Pandey L.K. |
spellingShingle |
Meenakumari K.J. Agarwal S. Krishna A. Pandey L.K. Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome Brazilian Journal of Medical and Biological Research Polycystic ovary syndrome Metformin Luteal phase defect Progesterone |
author_facet |
Meenakumari K.J. Agarwal S. Krishna A. Pandey L.K. |
author_sort |
Meenakumari K.J. |
title |
Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
title_short |
Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
title_full |
Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
title_fullStr |
Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
title_full_unstemmed |
Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
title_sort |
effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 0034-7310 |
publishDate |
2004-01-01 |
description |
The causes of luteal phase progesterone deficiency in polycystic ovary syndrome (PCOS) are not known. To determine the possible involvement of hyperinsulinemia in luteal phase progesterone deficiency in women with PCOS, we examined the relationship between progesterone, luteinizing hormone (LH) and insulin during the luteal phase and studied the effect of metformin on luteal progesterone levels in PCOS. Patients with PCOS (19 women aged 18-35 years) were treated with metformin (500 mg three times daily) for 4 weeks prior to the test cycle and throughout the study period, and submitted to ovulation induction with clomiphene citrate. Blood samples were collected from control (N = 5, same age range as PCOS women) and PCOS women during the late follicular (one sample) and luteal (3 samples) phases and LH, insulin and progesterone concentrations were determined. Results were analyzed by one-way analysis of variance (ANOVA), Duncan's test and Karl Pearson's coefficient of correlation (r). The endocrine study showed low progesterone level (4.9 ng/ml) during luteal phase in the PCOS women as compared with control (21.6 ng/ml). A significant negative correlation was observed between insulin and progesterone (r = -0.60; P < 0.01) and between progesterone and LH (r = -0.56; P < 0.05) concentrations, and a positive correlation (r = 0.83; P < 0.001) was observed between LH and insulin. The study further demonstrated a significant enhancement in luteal progesterone concentration (16.97 ng/ml) in PCOS women treated with metformin. The results suggest that hyperinsulinemia/insulin resistance may be responsible for low progesterone levels during the luteal phase in PCOS. The luteal progesterone level may be enhanced in PCOS by decreasing insulin secretion with metformin. |
topic |
Polycystic ovary syndrome Metformin Luteal phase defect Progesterone |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001100007 |
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