A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials
Objective. The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN). Method. Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time...
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Online Access: | http://dx.doi.org/10.1155/2018/7474207 |
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doaj-3098cfcc3d3a418893a045a08d06350e2020-11-25T02:28:07ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/74742077474207A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled TrialsMeng Zhang0Cun-Xiang Gao1Ke-Tao Ma2Li Li3Zhi-Gang Dai4Sheng Wang5Jun-Qiang Si6Department of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, ChinaDepartment of Urology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, ChinaElectrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, ChinaElectrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, ChinaDepartment of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, ChinaDepartment of Anesthesiology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi 832002, ChinaElectrophysiological Laboratory, Laboratory of Xinjiang Endemic and Ethnic Diseases, ChinaObjective. The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN). Method. Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time of inception to April 2017, in order to collect data on randomized controlled trials (RCTs) of gabapentin and placebo in PHN treatment. Results. A total of 11 RCTs (2376 people) were retrieved. The gabapentin group reported significantly reduced pain intensity [MD=−0.91, 95% CI −1.32 to −0.51, P<0.00001] compared with the placebo group. Those treated with gabapentin also experienced significantly improved sleep quality [SMD=−0.44, 95% CI −0.66 to −0.23, P<0.0001], but were more likely to experience incidence of adverse events, such as somnolence, dizziness, and peripheral edema. Results of the subgroup analysis showed that the source of heterogeneity may be related to the formulations of the drug. Conclusion. Gabapentin can be used to effectively and safely treat PHN.http://dx.doi.org/10.1155/2018/7474207 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng Zhang Cun-Xiang Gao Ke-Tao Ma Li Li Zhi-Gang Dai Sheng Wang Jun-Qiang Si |
spellingShingle |
Meng Zhang Cun-Xiang Gao Ke-Tao Ma Li Li Zhi-Gang Dai Sheng Wang Jun-Qiang Si A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials BioMed Research International |
author_facet |
Meng Zhang Cun-Xiang Gao Ke-Tao Ma Li Li Zhi-Gang Dai Sheng Wang Jun-Qiang Si |
author_sort |
Meng Zhang |
title |
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials |
title_short |
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials |
title_full |
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials |
title_fullStr |
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials |
title_full_unstemmed |
A Meta-Analysis of Therapeutic Efficacy and Safety of Gabapentin in the Treatment of Postherpetic Neuralgia from Randomized Controlled Trials |
title_sort |
meta-analysis of therapeutic efficacy and safety of gabapentin in the treatment of postherpetic neuralgia from randomized controlled trials |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
Objective. The study aims to systematically evaluate the clinical effect of gabapentin in the treatment of postherpetic neuralgia (PHN). Method. Data were retrieved electronically from PubMed, Embase, CNKI, the China Biomedical Database, and the Library of Clinical Database, beginning from the time of inception to April 2017, in order to collect data on randomized controlled trials (RCTs) of gabapentin and placebo in PHN treatment. Results. A total of 11 RCTs (2376 people) were retrieved. The gabapentin group reported significantly reduced pain intensity [MD=−0.91, 95% CI −1.32 to −0.51, P<0.00001] compared with the placebo group. Those treated with gabapentin also experienced significantly improved sleep quality [SMD=−0.44, 95% CI −0.66 to −0.23, P<0.0001], but were more likely to experience incidence of adverse events, such as somnolence, dizziness, and peripheral edema. Results of the subgroup analysis showed that the source of heterogeneity may be related to the formulations of the drug. Conclusion. Gabapentin can be used to effectively and safely treat PHN. |
url |
http://dx.doi.org/10.1155/2018/7474207 |
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