A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis

Introduction: Hard metal pneumoconiosis is a rare but serious disease of the lungs associated with inhalational exposure to tungsten or cobalt dust. Little is known about the radiologic and pathologic characteristics of this disease and the efficacy of treating with immunosuppression. Objective: We...

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Main Authors:	J. Chiarchiaro, L.R. Tomsic, S. Strock, K.L. Veraldi, M. Nouraie, J. Sellares, K.O. Lindell, L.A. Ortiz, F.C. Sciurba, R.F. Kucera, S.A. Yousem, C.R. Fuhrman, D.J. Kass, K.F. Gibson
Format:	Article
Language:	English
Published:	Elsevier 2018-01-01
Series:	Respiratory Medicine Case Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213007118301916

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record_format	Article
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	J. Chiarchiaro L.R. Tomsic S. Strock K.L. Veraldi M. Nouraie J. Sellares K.O. Lindell L.A. Ortiz F.C. Sciurba R.F. Kucera S.A. Yousem C.R. Fuhrman D.J. Kass K.F. Gibson
spellingShingle	J. Chiarchiaro L.R. Tomsic S. Strock K.L. Veraldi M. Nouraie J. Sellares K.O. Lindell L.A. Ortiz F.C. Sciurba R.F. Kucera S.A. Yousem C.R. Fuhrman D.J. Kass K.F. Gibson A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis Respiratory Medicine Case Reports
author_facet	J. Chiarchiaro L.R. Tomsic S. Strock K.L. Veraldi M. Nouraie J. Sellares K.O. Lindell L.A. Ortiz F.C. Sciurba R.F. Kucera S.A. Yousem C.R. Fuhrman D.J. Kass K.F. Gibson
author_sort	J. Chiarchiaro
title	A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
title_short	A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
title_full	A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
title_fullStr	A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
title_full_unstemmed	A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
title_sort	case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis
publisher	Elsevier
series	Respiratory Medicine Case Reports
issn	2213-0071
publishDate	2018-01-01
description	Introduction: Hard metal pneumoconiosis is a rare but serious disease of the lungs associated with inhalational exposure to tungsten or cobalt dust. Little is known about the radiologic and pathologic characteristics of this disease and the efficacy of treating with immunosuppression. Objective: We describe the largest cohort of patients with hard metal pneumoconiosis in the literature, including radiographic and pathologic patterns as well as treatment options. Methods: We retrospectively identified patients from the University of Pittsburgh pathology registry between the years of 1985 and 2016. Experts in chest radiology and pulmonary pathology reviewed the cases for radiologic and pathologic patterns. Results: We identified 23 patients with a pathologic pattern of hard metal pneumoconiosis. The most common radiographic findings were ground glass opacities (93%) and small nodules (64%). Of 20 surgical biopsies, 17 (85%) showed features of giant cell interstitial pneumonia. Most patients received systemic corticosteroids and/or steroid-sparing immunosuppression. Conclusions: Hard metal pneumoconiosis is characterized predominately by radiographic ground glass opacities and giant cell interstitial pneumonia on histopathology. Systemic corticosteroids and steroid-sparing immunosuppression are common treatment options. Keywords: Lung diseases, Interstitial, Hard metal pneumoconiosis, Giant cell interstitial pneumonia
url	http://www.sciencedirect.com/science/article/pii/S2213007118301916
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spelling	doaj-30a3a2a73bc5472c9cbef65cc36d17dd2020-11-25T02:19:01ZengElsevierRespiratory Medicine Case Reports2213-00712018-01-0125124128A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosisJ. Chiarchiaro0L.R. Tomsic1S. Strock2K.L. Veraldi3M. Nouraie4J. Sellares5K.O. Lindell6L.A. Ortiz7F.C. Sciurba8R.F. Kucera9S.A. Yousem10C.R. Fuhrman11D.J. Kass12K.F. Gibson13Division of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; Corresponding author. 628NW MUH 3459 Fifth Ave, Pittsburgh PA, 15213, USA.Division of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; Interstitial Lung Disease Program, Servei de Pneumologia, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Barcelona, SpainDivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Occupational Medicine, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USAExcela Westmoreland Hospital, Greensburg PA, USADepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh PA, USADepartment of Radiology, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USADivision of Pulmonary Allergy and Critical Care, University of Pittsburgh School of Medicine, Pittsburgh PA, USA; The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease, University of Pittsburgh School of Medicine, Pittsburgh PA, USAIntroduction: Hard metal pneumoconiosis is a rare but serious disease of the lungs associated with inhalational exposure to tungsten or cobalt dust. Little is known about the radiologic and pathologic characteristics of this disease and the efficacy of treating with immunosuppression. Objective: We describe the largest cohort of patients with hard metal pneumoconiosis in the literature, including radiographic and pathologic patterns as well as treatment options. Methods: We retrospectively identified patients from the University of Pittsburgh pathology registry between the years of 1985 and 2016. Experts in chest radiology and pulmonary pathology reviewed the cases for radiologic and pathologic patterns. Results: We identified 23 patients with a pathologic pattern of hard metal pneumoconiosis. The most common radiographic findings were ground glass opacities (93%) and small nodules (64%). Of 20 surgical biopsies, 17 (85%) showed features of giant cell interstitial pneumonia. Most patients received systemic corticosteroids and/or steroid-sparing immunosuppression. Conclusions: Hard metal pneumoconiosis is characterized predominately by radiographic ground glass opacities and giant cell interstitial pneumonia on histopathology. Systemic corticosteroids and steroid-sparing immunosuppression are common treatment options. Keywords: Lung diseases, Interstitial, Hard metal pneumoconiosis, Giant cell interstitial pneumoniahttp://www.sciencedirect.com/science/article/pii/S2213007118301916

A case series describing common radiographic and pathologic patterns of hard metal pneumoconiosis

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