Antiprotozoal action of synthetic cinnamic acid analogs

Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying n...

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Main Authors:	Ana Paula de Azevedo dos Santos, Saara Nery Fialho, Daniel Sol Sol de Medeiros, Ana Fidelina Gómez Garay, Jorge Alfonso Ruiz Diaz, Maria Celeste Vega Gómez, Carolina Bioni Garcia Teles, Leonardo de Azevedo Calderon
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical (SBMT)
Series:	Revista da Sociedade Brasileira de Medicina Tropical
Subjects:	Bioactivity Cinnamic acid Leishmaniasis Synthetic
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000600849&lng=en&tlng=en

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spelling	doaj-30aafd7459ad4cfb8286e1da09bdd4a12020-11-24T21:59:07ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-984951684985310.1590/0037-8682-0499-2017S0037-86822018000600849Antiprotozoal action of synthetic cinnamic acid analogsAna Paula de Azevedo dos SantosSaara Nery FialhoDaniel Sol Sol de MedeirosAna Fidelina Gómez GarayJorge Alfonso Ruiz DiazMaria Celeste Vega GómezCarolina Bioni Garcia TelesLeonardo de Azevedo CalderonAbstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000600849&lng=en&tlng=enBioactivityCinnamic acidLeishmaniasisSynthetic
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ana Paula de Azevedo dos Santos Saara Nery Fialho Daniel Sol Sol de Medeiros Ana Fidelina Gómez Garay Jorge Alfonso Ruiz Diaz Maria Celeste Vega Gómez Carolina Bioni Garcia Teles Leonardo de Azevedo Calderon
spellingShingle	Ana Paula de Azevedo dos Santos Saara Nery Fialho Daniel Sol Sol de Medeiros Ana Fidelina Gómez Garay Jorge Alfonso Ruiz Diaz Maria Celeste Vega Gómez Carolina Bioni Garcia Teles Leonardo de Azevedo Calderon Antiprotozoal action of synthetic cinnamic acid analogs Revista da Sociedade Brasileira de Medicina Tropical Bioactivity Cinnamic acid Leishmaniasis Synthetic
author_facet	Ana Paula de Azevedo dos Santos Saara Nery Fialho Daniel Sol Sol de Medeiros Ana Fidelina Gómez Garay Jorge Alfonso Ruiz Diaz Maria Celeste Vega Gómez Carolina Bioni Garcia Teles Leonardo de Azevedo Calderon
author_sort	Ana Paula de Azevedo dos Santos
title	Antiprotozoal action of synthetic cinnamic acid analogs
title_short	Antiprotozoal action of synthetic cinnamic acid analogs
title_full	Antiprotozoal action of synthetic cinnamic acid analogs
title_fullStr	Antiprotozoal action of synthetic cinnamic acid analogs
title_full_unstemmed	Antiprotozoal action of synthetic cinnamic acid analogs
title_sort	antiprotozoal action of synthetic cinnamic acid analogs
publisher	Sociedade Brasileira de Medicina Tropical (SBMT)
series	Revista da Sociedade Brasileira de Medicina Tropical
issn	1678-9849
description	Abstract INTRODUCTION Leishmaniasis, Chagas disease, and malaria cause morbidity globally. The drugs currently used for treatment have limitations. Activity of cinnamic acid analogs against Leishmania spp., Trypanosoma cruzi, and Plasmodium falciparum was evaluated in the interest of identifying new antiprotozoal compounds. METHODS In vitro effects of analogs against L. braziliensis, L. infantum chagasi, T. cruzi, and P. falciparum, and hemolytic and cytotoxic activities on NCTC 929 were determined. RESULTS Three analogs showed leishmanicidal and tripanocidal activity. No antiplasmodial, hemolytic, or cytotoxic activity was observed. CONCLUSIONS Antiprotozoal activity of analogs against L. infantum braziliensis, L. infantum chagasi, and T. cruzi was demonstrated.
topic	Bioactivity Cinnamic acid Leishmaniasis Synthetic
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000600849&lng=en&tlng=en
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Antiprotozoal action of synthetic cinnamic acid analogs

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