A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.
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2017-05-01
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Online Access: | https://doi.org/10.1038/ncomms15622 |
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doaj-30abb6e59ccc403ba1c9e976c95d4eef2021-05-11T07:15:39ZengNature Publishing GroupNature Communications2041-17232017-05-018111610.1038/ncomms15622A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancersGiuseppina Pisignano0Sara Napoli1Marco Magistri2Sarah N. Mapelli3Chiara Pastori4Stefano Di Marco5Gianluca Civenni6Domenico Albino7Claudia Enriquez8Sara Allegrini9Abhishek Mitra10Gioacchino D’Ambrosio11Maurizia Mello-Grand12Giovanna Chiorino13Ramon Garcia-Escudero14Gabriele Varani15Giuseppina M. Carbone16Carlo V. Catapano17Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)IRCCS MultimedicaLaboratory of Cancer Genomics, Fondo Edo TempiaLaboratory of Cancer Genomics, Fondo Edo TempiaTumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Department of Chemistry, University of WashingtonTumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.https://doi.org/10.1038/ncomms15622 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giuseppina Pisignano Sara Napoli Marco Magistri Sarah N. Mapelli Chiara Pastori Stefano Di Marco Gianluca Civenni Domenico Albino Claudia Enriquez Sara Allegrini Abhishek Mitra Gioacchino D’Ambrosio Maurizia Mello-Grand Giovanna Chiorino Ramon Garcia-Escudero Gabriele Varani Giuseppina M. Carbone Carlo V. Catapano |
spellingShingle |
Giuseppina Pisignano Sara Napoli Marco Magistri Sarah N. Mapelli Chiara Pastori Stefano Di Marco Gianluca Civenni Domenico Albino Claudia Enriquez Sara Allegrini Abhishek Mitra Gioacchino D’Ambrosio Maurizia Mello-Grand Giovanna Chiorino Ramon Garcia-Escudero Gabriele Varani Giuseppina M. Carbone Carlo V. Catapano A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers Nature Communications |
author_facet |
Giuseppina Pisignano Sara Napoli Marco Magistri Sarah N. Mapelli Chiara Pastori Stefano Di Marco Gianluca Civenni Domenico Albino Claudia Enriquez Sara Allegrini Abhishek Mitra Gioacchino D’Ambrosio Maurizia Mello-Grand Giovanna Chiorino Ramon Garcia-Escudero Gabriele Varani Giuseppina M. Carbone Carlo V. Catapano |
author_sort |
Giuseppina Pisignano |
title |
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers |
title_short |
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers |
title_full |
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers |
title_fullStr |
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers |
title_full_unstemmed |
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers |
title_sort |
promoter-proximal transcript targeted by genetic polymorphism controls e-cadherin silencing in human cancers |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-05-01 |
description |
Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers. |
url |
https://doi.org/10.1038/ncomms15622 |
work_keys_str_mv |
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