A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers

Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.

Bibliographic Details
Main Authors: Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone, Carlo V. Catapano
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15622
id doaj-30abb6e59ccc403ba1c9e976c95d4eef
record_format Article
spelling doaj-30abb6e59ccc403ba1c9e976c95d4eef2021-05-11T07:15:39ZengNature Publishing GroupNature Communications2041-17232017-05-018111610.1038/ncomms15622A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancersGiuseppina Pisignano0Sara Napoli1Marco Magistri2Sarah N. Mapelli3Chiara Pastori4Stefano Di Marco5Gianluca Civenni6Domenico Albino7Claudia Enriquez8Sara Allegrini9Abhishek Mitra10Gioacchino D’Ambrosio11Maurizia Mello-Grand12Giovanna Chiorino13Ramon Garcia-Escudero14Gabriele Varani15Giuseppina M. Carbone16Carlo V. Catapano17Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)IRCCS MultimedicaLaboratory of Cancer Genomics, Fondo Edo TempiaLaboratory of Cancer Genomics, Fondo Edo TempiaTumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Department of Chemistry, University of WashingtonTumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research (IOR), and Oncology Institute of Southern Switzerland (IOSI)Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.https://doi.org/10.1038/ncomms15622
collection DOAJ
language English
format Article
sources DOAJ
author Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
spellingShingle Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
Nature Communications
author_facet Giuseppina Pisignano
Sara Napoli
Marco Magistri
Sarah N. Mapelli
Chiara Pastori
Stefano Di Marco
Gianluca Civenni
Domenico Albino
Claudia Enriquez
Sara Allegrini
Abhishek Mitra
Gioacchino D’Ambrosio
Maurizia Mello-Grand
Giovanna Chiorino
Ramon Garcia-Escudero
Gabriele Varani
Giuseppina M. Carbone
Carlo V. Catapano
author_sort Giuseppina Pisignano
title A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_short A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_full A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_fullStr A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_full_unstemmed A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers
title_sort promoter-proximal transcript targeted by genetic polymorphism controls e-cadherin silencing in human cancers
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadherin in epithelial cancers.
url https://doi.org/10.1038/ncomms15622
work_keys_str_mv AT giuseppinapisignano apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT saranapoli apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT marcomagistri apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT sarahnmapelli apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT chiarapastori apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT stefanodimarco apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gianlucacivenni apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT domenicoalbino apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT claudiaenriquez apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT saraallegrini apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT abhishekmitra apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gioacchinodambrosio apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT mauriziamellogrand apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT giovannachiorino apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT ramongarciaescudero apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gabrielevarani apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT giuseppinamcarbone apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT carlovcatapano apromoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT giuseppinapisignano promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT saranapoli promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT marcomagistri promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT sarahnmapelli promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT chiarapastori promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT stefanodimarco promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gianlucacivenni promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT domenicoalbino promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT claudiaenriquez promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT saraallegrini promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT abhishekmitra promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gioacchinodambrosio promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT mauriziamellogrand promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT giovannachiorino promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT ramongarciaescudero promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT gabrielevarani promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT giuseppinamcarbone promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
AT carlovcatapano promoterproximaltranscripttargetedbygeneticpolymorphismcontrolsecadherinsilencinginhumancancers
_version_ 1721452557296992256

Similar Items