Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes.

Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes.

Mismatch between the uptake and utilization of long-chain fatty acids in the myocardium leads to abnormally high intracellular fatty acid concentration, which ultimately induces myocardial dysfunction. Stearoyl-Coenzyme A desaturase-1 (SCD1) is a rate-limiting enzyme that converts saturated fatty ac...

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Bibliographic Details
Main Authors: Hiroki Matsui, Tomoyuki Yokoyama, Kenichi Sekiguchi, Daisuke Iijima, Hiroaki Sunaga, Moeno Maniwa, Manabu Ueno, Tatsuya Iso, Masashi Arai, Masahiko Kurabayashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3297642?pdf=render

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