Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition
Abstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well unde...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-07-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-68143-7 |
id |
doaj-30b70b931331474cb60178c3f2da80ff |
---|---|
record_format |
Article |
spelling |
doaj-30b70b931331474cb60178c3f2da80ff2021-07-11T11:24:36ZengNature Publishing GroupScientific Reports2045-23222020-07-0110111110.1038/s41598-020-68143-7Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutritionGerard Bryan Gonzales0James M. Njunge1Bonface M. Gichuki2Bijun Wen3Isabel Potani4Wieger Voskuijl5Robert H. J. Bandsma6James A. Berkley7Department of Gastroenterology, Faculty of Medicine and Health Sciences, Ghent UniversityThe Childhood Acute Illness & Nutrition (CHAIN) NetworkThe Childhood Acute Illness & Nutrition (CHAIN) NetworkCentre for Global Child Health, The Hospital for Sick ChildrenThe Childhood Acute Illness & Nutrition (CHAIN) NetworkThe Childhood Acute Illness & Nutrition (CHAIN) NetworkThe Childhood Acute Illness & Nutrition (CHAIN) NetworkThe Childhood Acute Illness & Nutrition (CHAIN) NetworkAbstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n = 113), HIV-infected children (n = 54) had evidence (false discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-α-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p < 0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM.https://doi.org/10.1038/s41598-020-68143-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley |
spellingShingle |
Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition Scientific Reports |
author_facet |
Gerard Bryan Gonzales James M. Njunge Bonface M. Gichuki Bijun Wen Isabel Potani Wieger Voskuijl Robert H. J. Bandsma James A. Berkley |
author_sort |
Gerard Bryan Gonzales |
title |
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition |
title_short |
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition |
title_full |
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition |
title_fullStr |
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition |
title_full_unstemmed |
Plasma proteomics reveals markers of metabolic stress in HIV infected children with severe acute malnutrition |
title_sort |
plasma proteomics reveals markers of metabolic stress in hiv infected children with severe acute malnutrition |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-07-01 |
description |
Abstract HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n = 113), HIV-infected children (n = 54) had evidence (false discovery rate (FDR) corrected p < 0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-α-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p < 0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM. |
url |
https://doi.org/10.1038/s41598-020-68143-7 |
work_keys_str_mv |
AT gerardbryangonzales plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT jamesmnjunge plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT bonfacemgichuki plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT bijunwen plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT isabelpotani plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT wiegervoskuijl plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT roberthjbandsma plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition AT jamesaberkley plasmaproteomicsrevealsmarkersofmetabolicstressinhivinfectedchildrenwithsevereacutemalnutrition |
_version_ |
1721309097809149952 |