SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors

SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors

A set of 25 novel, silicon-based carbamate derivatives as potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors was synthesized and characterized by their in vitro inhibition profiles and the selectivity indexes (SIs). The prepared compounds were also tested for their inhibition potenti...

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Bibliographic Details
Main Authors: Andrzej Bak, Hana Pizova, Violetta Kozik, Katarina Vorcakova, Jiri Kos, Jakub Treml, Klara Odehnalova, Michal Oravec, Ales Imramovsky, Pavel Bobal, Adam Smolinski, Zdeněk Trávníček, Josef Jampilek
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
silicon-based carbamates
in vitro cholinesterase inhibition
comsa
ive-pls
molecular docking
similarity-activity landscape index
Online Access:https://www.mdpi.com/1422-0067/20/21/5385

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