Time-varying pattern of recurrence risk for localized melanoma in China
Abstract Background Acral and mucosal melanomas are rarely seen in Caucasians but common in China. There are limited data on the recurrence characteristics for these patients. This study aimed to identify the recurrence pattern for localized melanoma in China, especially acral and mucosal subtypes....
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doaj-30c6f3954e8843deaa4b04d95c95b7162021-01-03T12:10:53ZengBMCWorld Journal of Surgical Oncology1477-78192020-01-0118111010.1186/s12957-019-1775-5Time-varying pattern of recurrence risk for localized melanoma in ChinaXizhi Wen0Dandan Li1Jingjing Zhao2Jingjing Li3Tao Yang4Ya Ding5Ruiqing Peng6Baoyan Zhu7Fuxue Huang8Xiaoshi Zhang9Biotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Orthopedics, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical SciencesBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterBiotherapy Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterAbstract Background Acral and mucosal melanomas are rarely seen in Caucasians but common in China. There are limited data on the recurrence characteristics for these patients. This study aimed to identify the recurrence pattern for localized melanoma in China, especially acral and mucosal subtypes. Methods Patients with localized melanoma who underwent radical resection between January 1999 and December 2014 in southern China were retrospectively reviewed. Survival and annual recurrence hazard were analyzed by Kaplan–Meier method and hazard function, respectively. Results Totally, 1012 patients were included (acral melanoma 400; chronic sun-induced damage (CSD)/non-CSD melanoma 314; mucosal melanoma 298). Recurrence was recorded in 808 patients (localized 14.1%; regional 29.6%, and distant 56.3%). Mucosal melanoma had local and M1c stage recurrence more frequently than cutaneous melanoma, but less frequent regional node relapse. There was no difference in recurrent site distribution between acral and CSD/non-CSD melanoma. The annual recurrence hazard curve for the entire cohort showed a double-peaked pattern with the first major peak in the second year after surgery and the second peak near the seventh year. Mucosal melanoma had a higher recurrence risk than cutaneous melanoma. Acral melanoma had a lower flat recurrence peak than CSD/non-CSD melanoma. Tumor thickness > 4.0 mm, ulceration, positive regional nodes, and wound infection were associated with a higher recurrence risk in cutaneous melanoma. Adjuvant therapy reduced the recurrence risk of cutaneous melanoma but not of mucosal melanoma. Conclusions This is a large cohort about the rule of recurrence risk in acral and mucosal melanoma and will provide an initial framework for development of surveillance and adjuvant strategy for Chinese melanoma patients.https://doi.org/10.1186/s12957-019-1775-5MelanomaRecurrence hazardChinese population |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xizhi Wen Dandan Li Jingjing Zhao Jingjing Li Tao Yang Ya Ding Ruiqing Peng Baoyan Zhu Fuxue Huang Xiaoshi Zhang |
spellingShingle |
Xizhi Wen Dandan Li Jingjing Zhao Jingjing Li Tao Yang Ya Ding Ruiqing Peng Baoyan Zhu Fuxue Huang Xiaoshi Zhang Time-varying pattern of recurrence risk for localized melanoma in China World Journal of Surgical Oncology Melanoma Recurrence hazard Chinese population |
author_facet |
Xizhi Wen Dandan Li Jingjing Zhao Jingjing Li Tao Yang Ya Ding Ruiqing Peng Baoyan Zhu Fuxue Huang Xiaoshi Zhang |
author_sort |
Xizhi Wen |
title |
Time-varying pattern of recurrence risk for localized melanoma in China |
title_short |
Time-varying pattern of recurrence risk for localized melanoma in China |
title_full |
Time-varying pattern of recurrence risk for localized melanoma in China |
title_fullStr |
Time-varying pattern of recurrence risk for localized melanoma in China |
title_full_unstemmed |
Time-varying pattern of recurrence risk for localized melanoma in China |
title_sort |
time-varying pattern of recurrence risk for localized melanoma in china |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2020-01-01 |
description |
Abstract Background Acral and mucosal melanomas are rarely seen in Caucasians but common in China. There are limited data on the recurrence characteristics for these patients. This study aimed to identify the recurrence pattern for localized melanoma in China, especially acral and mucosal subtypes. Methods Patients with localized melanoma who underwent radical resection between January 1999 and December 2014 in southern China were retrospectively reviewed. Survival and annual recurrence hazard were analyzed by Kaplan–Meier method and hazard function, respectively. Results Totally, 1012 patients were included (acral melanoma 400; chronic sun-induced damage (CSD)/non-CSD melanoma 314; mucosal melanoma 298). Recurrence was recorded in 808 patients (localized 14.1%; regional 29.6%, and distant 56.3%). Mucosal melanoma had local and M1c stage recurrence more frequently than cutaneous melanoma, but less frequent regional node relapse. There was no difference in recurrent site distribution between acral and CSD/non-CSD melanoma. The annual recurrence hazard curve for the entire cohort showed a double-peaked pattern with the first major peak in the second year after surgery and the second peak near the seventh year. Mucosal melanoma had a higher recurrence risk than cutaneous melanoma. Acral melanoma had a lower flat recurrence peak than CSD/non-CSD melanoma. Tumor thickness > 4.0 mm, ulceration, positive regional nodes, and wound infection were associated with a higher recurrence risk in cutaneous melanoma. Adjuvant therapy reduced the recurrence risk of cutaneous melanoma but not of mucosal melanoma. Conclusions This is a large cohort about the rule of recurrence risk in acral and mucosal melanoma and will provide an initial framework for development of surveillance and adjuvant strategy for Chinese melanoma patients. |
topic |
Melanoma Recurrence hazard Chinese population |
url |
https://doi.org/10.1186/s12957-019-1775-5 |
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