Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian can...

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Main Authors:	Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25684-3

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spelling	doaj-30c7f569e8f14f29b50078b914b06fde2021-09-12T11:46:51ZengNature Publishing GroupNature Communications2041-17232021-09-0112111410.1038/s41467-021-25684-3Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancerJianhuang Lin0Heng Liu1Takeshi Fukumoto2Joseph Zundell3Qingqing Yan4Chih-Hang Anthony Tang5Shuai Wu6Wei Zhou7Dajiang Guo8Sergey Karakashev9Chih-Chi Andrew Hu10Kavitha Sarma11Andrew V. Kossenkov12Rugang Zhang13Immunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteGene Expression and Regulation Program, The Wistar InstituteCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteCenter for Translational Research in Hematologic Malignancies, Houston Methodist Cancer Center, Houston Methodist Research InstituteGene Expression and Regulation Program, The Wistar InstituteGene Expression and Regulation Program, The Wistar InstituteImmunology, Microenvironment and Metastasis Program, The Wistar InstituteThe unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.https://doi.org/10.1038/s41467-021-25684-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang
spellingShingle	Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer Nature Communications
author_facet	Jianhuang Lin Heng Liu Takeshi Fukumoto Joseph Zundell Qingqing Yan Chih-Hang Anthony Tang Shuai Wu Wei Zhou Dajiang Guo Sergey Karakashev Chih-Chi Andrew Hu Kavitha Sarma Andrew V. Kossenkov Rugang Zhang
author_sort	Jianhuang Lin
title	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_short	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_full	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_fullStr	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_full_unstemmed	Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
title_sort	targeting the ire1α/xbp1s pathway suppresses carm1-expressing ovarian cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-09-01
description	The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway can inhibit growth in CARM1 expressing ovarian cancers.
url	https://doi.org/10.1038/s41467-021-25684-3
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer

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