Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas

Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas

Abstract Background Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets are needed. Several studies not only reported mutations but also amplifi...

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Bibliographic Details
Main Authors: Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Cancer
Subjects:
KRAS amplification
Gastric adenocarcinoma
Prognosis
Fluorescence-in-situ-hybridization (FISH)
Heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12885-020-06996-x

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http://link.springer.com/article/10.1186/s12885-020-06996-x

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