Amplification of KRAS and its heterogeneity in non-Asian gastric adenocarcinomas
Abstract Background Gastric cancer is one of the deadliest cancer entities worldwide. While surgery is the only curative treatment option in early tumors, for locally advanced and metastatic patients further therapeutic targets are needed. Several studies not only reported mutations but also amplifi...
Main Authors: | Jan Rehkaemper, Michael Korenkov, Alexander Quaas, Josef Rueschoff, Aylin Pamuk, Thomas Zander, Axel M. Hillmer, Reinhard Buettner, Arnulf Heinrich Hoelscher, Christiane Josephine Bruns, Heike Loeser, Hakan Alakus, Birgid Schoemig-Markiefka |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
|
Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-020-06996-x |
Similar Items
-
Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center
by: Alexander Quaas, et al.
Published: (2021-07-01) -
Durable Response to Crizotinib in a MET-Amplified, KRAS-Mutated Carcinoma of Unknown Primary
by: Norma A. Palma, et al.
Published: (2014-07-01) -
KRAS and MAPK1 Gene Amplification in Type II Ovarian Carcinomas
by: Noriyuki Ishikawa, et al.
Published: (2013-07-01) -
PIK3CA and KRAS Amplification in Esophageal Adenocarcinoma and their Impact on the Inflammatory Tumor Microenvironment and Prognosis
by: Ahlem Essakly, et al.
Published: (2020-02-01) -
Kontaktni kras v Kočevskem Rogu in Kočevski Mali gori
by: Petra Gostinčar
Published: (2011-12-01)