Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment
<p>Abstract</p> <p>Background</p> <p>Renal cell carcinoma (RCC) represents approximately 3% of all adult cancers and is more common in males. Systemic treatment for RCC has improved following the introduction of tyrosine kinase inhibitors, such as sunitinib. The molecul...
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doaj-30e4fb4f986e4f7985b9e209c96aec952020-11-25T01:17:21ZengBMCWorld Journal of Surgical Oncology1477-78192010-05-01814510.1186/1477-7819-8-45Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatmentGennatas ConstantineKondi-Pafiti AgathiArkadopoulos NikolaosMichalaki Vasiliki<p>Abstract</p> <p>Background</p> <p>Renal cell carcinoma (RCC) represents approximately 3% of all adult cancers and is more common in males. Systemic treatment for RCC has improved following the introduction of tyrosine kinase inhibitors, such as sunitinib. The molecular targets of sunitinib are receptor tyrosine kinases (RTKs). Moreover, sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation.</p> <p>Case presentation</p> <p>We present a case of intra-abdominal abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment.</p> <p>Conclusion</p> <p>In the advancing era of molecular therapy of solid tumours, sunitinib has demonstrated significant efficacy in the post-cytokine setting treatment of metastatic renal cancer. Concurrently, however, increasing evidence has emerged to indicate that this class of drugs exert profound immunomodulatory effects on T cells and play major roles in immune tumor surveillance.</p> http://www.wjso.com/content/8/1/45 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gennatas Constantine Kondi-Pafiti Agathi Arkadopoulos Nikolaos Michalaki Vasiliki |
spellingShingle |
Gennatas Constantine Kondi-Pafiti Agathi Arkadopoulos Nikolaos Michalaki Vasiliki Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment World Journal of Surgical Oncology |
author_facet |
Gennatas Constantine Kondi-Pafiti Agathi Arkadopoulos Nikolaos Michalaki Vasiliki |
author_sort |
Gennatas Constantine |
title |
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
title_short |
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
title_full |
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
title_fullStr |
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
title_full_unstemmed |
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
title_sort |
abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment |
publisher |
BMC |
series |
World Journal of Surgical Oncology |
issn |
1477-7819 |
publishDate |
2010-05-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Renal cell carcinoma (RCC) represents approximately 3% of all adult cancers and is more common in males. Systemic treatment for RCC has improved following the introduction of tyrosine kinase inhibitors, such as sunitinib. The molecular targets of sunitinib are receptor tyrosine kinases (RTKs). Moreover, sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation.</p> <p>Case presentation</p> <p>We present a case of intra-abdominal abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment.</p> <p>Conclusion</p> <p>In the advancing era of molecular therapy of solid tumours, sunitinib has demonstrated significant efficacy in the post-cytokine setting treatment of metastatic renal cancer. Concurrently, however, increasing evidence has emerged to indicate that this class of drugs exert profound immunomodulatory effects on T cells and play major roles in immune tumor surveillance.</p> |
url |
http://www.wjso.com/content/8/1/45 |
work_keys_str_mv |
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1725146425388433408 |