Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, t...

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Main Authors:	C. Johnston, C. Hardacre, M. E. Migaud
Format:	Article
Language:	English
Published:	The Royal Society 2021-03-01
Series:	Royal Society Open Science
Subjects:	mechanochemistry organophosphorus dinucleotides
Online Access:	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201703

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spelling	doaj-30e72dfbe4624028aedec8d35c391a892021-04-14T10:31:34ZengThe Royal SocietyRoyal Society Open Science2054-57032021-03-018310.1098/rsos.201703201703Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistryC. JohnstonC. HardacreM. E. MigaudLiquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201703mechanochemistryorganophosphorusdinucleotides
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	C. Johnston C. Hardacre M. E. Migaud
spellingShingle	C. Johnston C. Hardacre M. E. Migaud Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry Royal Society Open Science mechanochemistry organophosphorus dinucleotides
author_facet	C. Johnston C. Hardacre M. E. Migaud
author_sort	C. Johnston
title	Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_short	Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_full	Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_fullStr	Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_full_unstemmed	Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
title_sort	investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry
publisher	The Royal Society
series	Royal Society Open Science
issn	2054-5703
publishDate	2021-03-01
description	Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.
topic	mechanochemistry organophosphorus dinucleotides
url	https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.201703
work_keys_str_mv	AT cjohnston investigationsintothesynthesisofanucleotidedimerviamechanochemicalphosphoramiditechemistry AT chardacre investigationsintothesynthesisofanucleotidedimerviamechanochemicalphosphoramiditechemistry AT memigaud investigationsintothesynthesisofanucleotidedimerviamechanochemicalphosphoramiditechemistry
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Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

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