Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study.
We wished to determine the prevalence of fever as one of the first symptoms of the enthesitis-related arthritis (ERA) subtype of juvenile idiopathic arthritis. Also, we wished to ascertain if ERA patients with fever at disease onset differed from those without fever.Consecutive cases of ERA were dia...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4451976?pdf=render |
id |
doaj-30f04d9eefed4b53ae13076fc90d4de9 |
---|---|
record_format |
Article |
spelling |
doaj-30f04d9eefed4b53ae13076fc90d4de92020-11-25T00:50:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012897910.1371/journal.pone.0128979Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study.Ruru GuoLanfang CaoXianming KongXuesong LiuHaiyan XueLijuan ShenXiaoli LiWe wished to determine the prevalence of fever as one of the first symptoms of the enthesitis-related arthritis (ERA) subtype of juvenile idiopathic arthritis. Also, we wished to ascertain if ERA patients with fever at disease onset differed from those without fever.Consecutive cases of ERA were diagnosed and followed in a retrospective observational study from 1998 to 2013. Information about clinical/laboratory data, medications, magnetic resonance imaging (MRI), and disease activity during the study period was also recorded.A total of 146 consecutive ERA patients were assessed. Among them, 52 patients (35.6%) had fever as one of the first symptoms at disease onset. Compared with ERA patients without fever at disease onset, patients with fever had significantly more painful joints (3.5 vs. 2.8), more swollen joints (1.1 vs. 0.8), and more enthesitis (1.0 vs. 0.4) (p<0.05 for all comparisons). Patients with fever had significantly higher mean values of erythrocyte sedimentation rate, C-reactive protein, platelet count, and child health assessment questionnaire (CHAQ) scores (40.8 vs. 26.4 mm/h; 20.7 vs. 9.7 mg/dL; 353.2×109/L vs. 275.6×109/L; 1.0 vs. 0.8, respectively; all p<0.05). During two-year follow-up, CHAQ score, number of flares, as well as the number of patients treated with oral non-steroidal anti-inflammatory drugs, corticosteroids and combination therapy with disease-modifying anti-rheumatic drugs, were significantly higher in ERA patients with fever.Fever was a frequent manifestation of ERA. ERA patients with fever had more active disease at disease onset and poorer outcomes than ERA patients without fever.http://europepmc.org/articles/PMC4451976?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruru Guo Lanfang Cao Xianming Kong Xuesong Liu Haiyan Xue Lijuan Shen Xiaoli Li |
spellingShingle |
Ruru Guo Lanfang Cao Xianming Kong Xuesong Liu Haiyan Xue Lijuan Shen Xiaoli Li Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. PLoS ONE |
author_facet |
Ruru Guo Lanfang Cao Xianming Kong Xuesong Liu Haiyan Xue Lijuan Shen Xiaoli Li |
author_sort |
Ruru Guo |
title |
Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
title_short |
Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
title_full |
Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
title_fullStr |
Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
title_full_unstemmed |
Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
title_sort |
fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
We wished to determine the prevalence of fever as one of the first symptoms of the enthesitis-related arthritis (ERA) subtype of juvenile idiopathic arthritis. Also, we wished to ascertain if ERA patients with fever at disease onset differed from those without fever.Consecutive cases of ERA were diagnosed and followed in a retrospective observational study from 1998 to 2013. Information about clinical/laboratory data, medications, magnetic resonance imaging (MRI), and disease activity during the study period was also recorded.A total of 146 consecutive ERA patients were assessed. Among them, 52 patients (35.6%) had fever as one of the first symptoms at disease onset. Compared with ERA patients without fever at disease onset, patients with fever had significantly more painful joints (3.5 vs. 2.8), more swollen joints (1.1 vs. 0.8), and more enthesitis (1.0 vs. 0.4) (p<0.05 for all comparisons). Patients with fever had significantly higher mean values of erythrocyte sedimentation rate, C-reactive protein, platelet count, and child health assessment questionnaire (CHAQ) scores (40.8 vs. 26.4 mm/h; 20.7 vs. 9.7 mg/dL; 353.2×109/L vs. 275.6×109/L; 1.0 vs. 0.8, respectively; all p<0.05). During two-year follow-up, CHAQ score, number of flares, as well as the number of patients treated with oral non-steroidal anti-inflammatory drugs, corticosteroids and combination therapy with disease-modifying anti-rheumatic drugs, were significantly higher in ERA patients with fever.Fever was a frequent manifestation of ERA. ERA patients with fever had more active disease at disease onset and poorer outcomes than ERA patients without fever. |
url |
http://europepmc.org/articles/PMC4451976?pdf=render |
work_keys_str_mv |
AT ruruguo feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT lanfangcao feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT xianmingkong feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT xuesongliu feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT haiyanxue feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT lijuanshen feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy AT xiaolili feverasaninitialmanifestationofenthesitisrelatedarthritissubtypeofjuvenileidiopathicarthritisretrospectivestudy |
_version_ |
1725246639303557120 |