A regularized functional regression model enabling transcriptome-wide dosage-dependent association study of cancer drug response.
Cancer treatments can be highly toxic and frequently only a subset of the patient population will benefit from a given treatment. Tumour genetic makeup plays an important role in cancer drug sensitivity. We suspect that gene expression markers could be used as a decision aid for treatment selection...
Main Authors: | Evanthia Koukouli, Dennis Wang, Frank Dondelinger, Juhyun Park |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2021-01-01
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Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1008066 |
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