Hyperbaric environment up-regulates CD15s expression on leukocytes, down-regulates CD77 expression on renal cells and up-regulates CD34 expression on pulmonary and cardiac cells in rat

• Main Authors: Danka Đevenica, Anita Markotić, Nikolina Režić-Mužinić, Igor Jelaska, Tatijana Zemunik, Hrvoje Delić, Vedrana Čikeš Čulić
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2016-08-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: CD15s(sialyl Lexis X antigen); CD77(globotriaosylceramide); CD34 antigen; Environment
• Online Access: http://ijbms.mums.ac.ir/article_7462_a245c794b6940b8b4a8333dd5a6c7879.pdf
• ISSN: 2008-3866; 2008-3874

Objective(s): The aim of this study was to estimate effects of hyperbaric (HB) treatment by determination of CD15s and CD11b leukocyte proinflammatory markers expression.  In addition, this study describes changes in CD77 and CD34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. Materials and Methods:Expression of CD11b and CD15s on leukocytes, as well as CD77 and CD34 expression on endothelial cells in cell suspensions of renal, pulmonary and cardiac tissue in rats after hyperbaric treatment and in control rats were determined by flow cytometry. Results: Hyperbaric treatment significantly increased percentage of leukocytes expressing CD15s+CD11b- (from 1.71±1.11 to 23.42±2.85, P