Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus

Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus

The relationship between gene expression and morphology to classify PV interneurons is unclear. Here, the authors show transcriptional continuity of morphologically distinct mouse hippocampal PV interneurons subtypes, combining single-cell RNA sequencing and electrophysiology.

Bibliographic Details
Main Authors: Lin Que, David Lukacsovich, Wenshu Luo, Csaba Földy
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20328-4
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spelling doaj-30fe6870647e4bc89e435480fcc57e662021-01-10T12:18:59ZengNature Publishing GroupNature Communications2041-17232021-01-0112111510.1038/s41467-020-20328-4Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampusLin Que0David Lukacsovich1Wenshu Luo2Csaba Földy3Laboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of ZürichLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of ZürichLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of ZürichLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of ZürichThe relationship between gene expression and morphology to classify PV interneurons is unclear. Here, the authors show transcriptional continuity of morphologically distinct mouse hippocampal PV interneurons subtypes, combining single-cell RNA sequencing and electrophysiology.https://doi.org/10.1038/s41467-020-20328-4
collection DOAJ
language English
format Article
sources DOAJ
author Lin Que
David Lukacsovich
Wenshu Luo
Csaba Földy
spellingShingle Lin Que
David Lukacsovich
Wenshu Luo
Csaba Földy
Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
Nature Communications
author_facet Lin Que
David Lukacsovich
Wenshu Luo
Csaba Földy
author_sort Lin Que
title Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
title_short Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
title_full Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
title_fullStr Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
title_full_unstemmed Transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
title_sort transcriptional and morphological profiling of parvalbumin interneuron subpopulations in the mouse hippocampus
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-01-01
description The relationship between gene expression and morphology to classify PV interneurons is unclear. Here, the authors show transcriptional continuity of morphologically distinct mouse hippocampal PV interneurons subtypes, combining single-cell RNA sequencing and electrophysiology.
url https://doi.org/10.1038/s41467-020-20328-4
work_keys_str_mv AT linque transcriptionalandmorphologicalprofilingofparvalbumininterneuronsubpopulationsinthemousehippocampus
AT davidlukacsovich transcriptionalandmorphologicalprofilingofparvalbumininterneuronsubpopulationsinthemousehippocampus
AT wenshuluo transcriptionalandmorphologicalprofilingofparvalbumininterneuronsubpopulationsinthemousehippocampus
AT csabafoldy transcriptionalandmorphologicalprofilingofparvalbumininterneuronsubpopulationsinthemousehippocampus
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