Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder
Objects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan.Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured in...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-08-01
|
Series: | Frontiers in Psychiatry |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00541/full |
id |
doaj-3106651c5a9d4b54848a10259e1ea99f |
---|---|
record_format |
Article |
spelling |
doaj-3106651c5a9d4b54848a10259e1ea99f2020-11-25T01:29:47ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-08-011010.3389/fpsyt.2019.00541445437Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive DisorderWei-Tsung Kao0Wei-Tsung Kao1Wei-Tsung Kao2Wei-Tsung Kao3Chen-Lin Chang4Chi-Hung Lin5Shang-Liang Wu6Shang-Lun Lin7For-Wey Lung8For-Wey Lung9Laboratory of Research, Kaohsiung Armed Forces General Hospital, Kaohsiung, TaiwanDepartment of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, TaiwanGraduate Institute of Medical Science, National Defense Medical Center, Taipei, TaiwanDepartment of Nursing, Shu Zen Junior College of Management and Medicine, Kaohsiung, TaiwanDepartment of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, TaiwanChi-hung Clinic, Kaohsiung, TaiwanSchool of Medicine, Griffith University, Gold Coast, AustraliaDepartment of Psychiatry, Kaohsiung Armed Forces General Hospital, Kaohsiung, TaiwanGraduate Institute of Medical Science, National Defense Medical Center, Taipei, TaiwanCalo Psychiatric Center, Pingtung County, TaiwanObjects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan.Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured individuals from 2005. A total of 743,114 outpatients were included in our study. We used PSM (nearest neighbor matching) stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score.Results: The hazard ratio (HR) of hypertension was significantly greater in the male MDD outpatients (HR = 1.116, P = 0.004) than in the female MDD outpatients (HR = 0.93, P = 0.02). Using PSM, we selected 27,988 outpatients with hypertension and 27,988 outpatients without hypertension for a nested case–control study. In this analysis, female outpatients with MDD (relative risk = 0.852) had lower risks of hypertension. Male outpatients without/with MDD (relative risk = 1.987/3.018) showed a synergistic interaction with gender in which male patients had a higher risk of hypertension in a multiplicative model. Furthermore, MDD appeared to have an interaction effect with gender (HR = 1.82, P < 0.001) in the proportional hazards model analysis. Antidepressant use also increased the risk of hypertension (HR = 1.16, P < 0.001).Conclusions: There was gender disparity in the risk of hypertension in subjects with MDD. MDD outpatients who used antidepressants had a higher risk of suffering from hypertension. A large-scale, population-based study is warranted to generalize these results in the future.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00541/fullmajor depressive disorder (MDD)propensity score matching (PSM)hypertensionrisk factorsNational Health Insurance Database |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Chen-Lin Chang Chi-Hung Lin Shang-Liang Wu Shang-Lun Lin For-Wey Lung For-Wey Lung |
spellingShingle |
Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Chen-Lin Chang Chi-Hung Lin Shang-Liang Wu Shang-Lun Lin For-Wey Lung For-Wey Lung Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder Frontiers in Psychiatry major depressive disorder (MDD) propensity score matching (PSM) hypertension risk factors National Health Insurance Database |
author_facet |
Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Wei-Tsung Kao Chen-Lin Chang Chi-Hung Lin Shang-Liang Wu Shang-Lun Lin For-Wey Lung For-Wey Lung |
author_sort |
Wei-Tsung Kao |
title |
Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder |
title_short |
Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder |
title_full |
Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder |
title_fullStr |
Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder |
title_full_unstemmed |
Gender Disparity in the Risk of Hypertension in Subjects With Major Depressive Disorder |
title_sort |
gender disparity in the risk of hypertension in subjects with major depressive disorder |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2019-08-01 |
description |
Objects: The aim of our study was to investigate whether major depressive disorder (MDD) increased the risk of hypertension using propensity score matching (PSM) in patients with MDD in Taiwan.Methods: In this study, we recruited all samples from a random sample sub-dataset of one million insured individuals from 2005. A total of 743,114 outpatients were included in our study. We used PSM (nearest neighbor matching) stratified by age, hospital level, insurance amount, and Charlson Comorbidity Index score.Results: The hazard ratio (HR) of hypertension was significantly greater in the male MDD outpatients (HR = 1.116, P = 0.004) than in the female MDD outpatients (HR = 0.93, P = 0.02). Using PSM, we selected 27,988 outpatients with hypertension and 27,988 outpatients without hypertension for a nested case–control study. In this analysis, female outpatients with MDD (relative risk = 0.852) had lower risks of hypertension. Male outpatients without/with MDD (relative risk = 1.987/3.018) showed a synergistic interaction with gender in which male patients had a higher risk of hypertension in a multiplicative model. Furthermore, MDD appeared to have an interaction effect with gender (HR = 1.82, P < 0.001) in the proportional hazards model analysis. Antidepressant use also increased the risk of hypertension (HR = 1.16, P < 0.001).Conclusions: There was gender disparity in the risk of hypertension in subjects with MDD. MDD outpatients who used antidepressants had a higher risk of suffering from hypertension. A large-scale, population-based study is warranted to generalize these results in the future. |
topic |
major depressive disorder (MDD) propensity score matching (PSM) hypertension risk factors National Health Insurance Database |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00541/full |
work_keys_str_mv |
AT weitsungkao genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT weitsungkao genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT weitsungkao genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT weitsungkao genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT chenlinchang genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT chihunglin genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT shangliangwu genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT shanglunlin genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT forweylung genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder AT forweylung genderdisparityintheriskofhypertensioninsubjectswithmajordepressivedisorder |
_version_ |
1725094756955979776 |