Purinergic targeting enhances immunotherapy of CD73+ solid tumors with piggyBac-engineered chimeric antigen receptor natural killer cells
Abstract Background The anti-tumor immunity of natural killer (NK) cells can be paralyzed by the CD73-induced generation of immunosuppressive adenosine from precursor ATP within the hypoxic microenvironment of solid tumors. In an effort to redirect purinergic immunosuppression of NK cell anti-tumor...
Main Authors: | Jiao Wang, Kyle B. Lupo, Andrea M. Chambers, Sandro Matosevic |
---|---|
Format: | Article |
Language: | English |
Published: |
BMJ Publishing Group
2018-12-01
|
Series: | Journal for ImmunoTherapy of Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40425-018-0441-8 |
Similar Items
-
Immunometabolic Dysfunction of Natural Killer Cells Mediated by the Hypoxia-CD73 Axis in Solid Tumors
by: Andrea M. Chambers, et al.
Published: (2019-07-01) -
Adenosinergic Signaling Alters Natural Killer Cell Functional Responses
by: Andrea M. Chambers, et al.
Published: (2018-10-01) -
<i>NT5E</i>/CD73 as Correlative Factor of Patient Survival and Natural Killer Cell Infiltration in Glioblastoma
by: Jiao Wang, et al.
Published: (2019-09-01) -
Tumor Microenvironment-Induced Immunometabolic Reprogramming of Natural Killer Cells
by: Andrea M. Chambers, et al.
Published: (2018-11-01) -
Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells
by: Daisuke Morita, et al.
Published: (2018-03-01)