Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eye...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-10-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/8/10/1636 |
id |
doaj-31118b10c894488aafcb7a5eabb8e71f |
---|---|
record_format |
Article |
spelling |
doaj-31118b10c894488aafcb7a5eabb8e71f2020-11-24T21:56:15ZengMDPI AGJournal of Clinical Medicine2077-03832019-10-01810163610.3390/jcm8101636jcm8101636Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT StudyMichele Nicolai0Alessandro Franceschi1Serena De Turris2Alessandro Rosati3Vittorio Pirani4Cesare Mariotti5Eye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyPurpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (<i>p</i> < 0.001), while mean BCVA improved from 0.70 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 ± 0.18 logMAR units after 4 months (<i>p</i> < 0.001). VD inside disc and peripapillary significantly increased (<i>p</i> < 0.001 and <i>p</i> = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema.https://www.mdpi.com/2077-0383/8/10/1636central retinal vein occlusionsanti-vegfoptical coherence tomography angiographyperipapillary vessel density |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michele Nicolai Alessandro Franceschi Serena De Turris Alessandro Rosati Vittorio Pirani Cesare Mariotti |
spellingShingle |
Michele Nicolai Alessandro Franceschi Serena De Turris Alessandro Rosati Vittorio Pirani Cesare Mariotti Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study Journal of Clinical Medicine central retinal vein occlusions anti-vegf optical coherence tomography angiography peripapillary vessel density |
author_facet |
Michele Nicolai Alessandro Franceschi Serena De Turris Alessandro Rosati Vittorio Pirani Cesare Mariotti |
author_sort |
Michele Nicolai |
title |
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study |
title_short |
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study |
title_full |
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study |
title_fullStr |
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study |
title_full_unstemmed |
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study |
title_sort |
papillary vessel density changes after intravitreal anti-vegf injections in hypertensive patients with central retinal vein occlusion: an angio-oct study |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-10-01 |
description |
Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (<i>p</i> < 0.001), while mean BCVA improved from 0.70 ± 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 ± 0.18 logMAR units after 4 months (<i>p</i> < 0.001). VD inside disc and peripapillary significantly increased (<i>p</i> < 0.001 and <i>p</i> = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema. |
topic |
central retinal vein occlusions anti-vegf optical coherence tomography angiography peripapillary vessel density |
url |
https://www.mdpi.com/2077-0383/8/10/1636 |
work_keys_str_mv |
AT michelenicolai papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy AT alessandrofranceschi papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy AT serenadeturris papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy AT alessandrorosati papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy AT vittoriopirani papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy AT cesaremariotti papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy |
_version_ |
1725858955960254464 |