Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study

Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eye...

Full description

Bibliographic Details
Main Authors: Michele Nicolai, Alessandro Franceschi, Serena De Turris, Alessandro Rosati, Vittorio Pirani, Cesare Mariotti
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/8/10/1636
id doaj-31118b10c894488aafcb7a5eabb8e71f
record_format Article
spelling doaj-31118b10c894488aafcb7a5eabb8e71f2020-11-24T21:56:15ZengMDPI AGJournal of Clinical Medicine2077-03832019-10-01810163610.3390/jcm8101636jcm8101636Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT StudyMichele Nicolai0Alessandro Franceschi1Serena De Turris2Alessandro Rosati3Vittorio Pirani4Cesare Mariotti5Eye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyEye Clinic, Polytechnic University of Marche, via Conca 61, 60126 Ancona, ItalyPurpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (<i>p</i> &lt; 0.001), while mean BCVA improved from 0.70 &#177; 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 &#177; 0.18 logMAR units after 4 months (<i>p</i> &lt; 0.001). VD inside disc and peripapillary significantly increased (<i>p</i> &lt; 0.001 and <i>p</i> = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema.https://www.mdpi.com/2077-0383/8/10/1636central retinal vein occlusionsanti-vegfoptical coherence tomography angiographyperipapillary vessel density
collection DOAJ
language English
format Article
sources DOAJ
author Michele Nicolai
Alessandro Franceschi
Serena De Turris
Alessandro Rosati
Vittorio Pirani
Cesare Mariotti
spellingShingle Michele Nicolai
Alessandro Franceschi
Serena De Turris
Alessandro Rosati
Vittorio Pirani
Cesare Mariotti
Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
Journal of Clinical Medicine
central retinal vein occlusions
anti-vegf
optical coherence tomography angiography
peripapillary vessel density
author_facet Michele Nicolai
Alessandro Franceschi
Serena De Turris
Alessandro Rosati
Vittorio Pirani
Cesare Mariotti
author_sort Michele Nicolai
title Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
title_short Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
title_full Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
title_fullStr Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
title_full_unstemmed Papillary Vessel Density Changes after Intravitreal Anti-VEGF Injections in Hypertensive Patients with Central Retinal Vein Occlusion: An Angio-OCT Study
title_sort papillary vessel density changes after intravitreal anti-vegf injections in hypertensive patients with central retinal vein occlusion: an angio-oct study
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2019-10-01
description Purpose: To investigate papillary microvascular changes in patients affected by macular edema due to Central Retinal Vein Occlusions (CRVO) after anti-Vascular Endothelial Growth Factor (VEGF) therapy. Methods: Prospective analysis of papillary and peripapillary vessel density (VD) changes in 18 eyes of 18 hypertensive patients affected by CRVO before and after the loading-phase of intravitreal Ranibizumab (IVR) injections. Data were quantitatively measured by optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) before as well as 1 month and 4 months after injections. The correlation between post-treatment best-corrected visual acuity (BCVA) and changes in the retinal microvasculature evaluated by OCTA was assessed. Results: 18 eyes of 18 consecutive patients with a known history of arterial hypertension and affected by an acute CRVO episode were enrolled. Central macular thickness (CMT) was significantly reduced after IVR injections (<i>p</i> &lt; 0.001), while mean BCVA improved from 0.70 &#177; 0.26 logarithm of the minimal angle of resolution (logMAR) units at baseline to 0.25 &#177; 0.18 logMAR units after 4 months (<i>p</i> &lt; 0.001). VD inside disc and peripapillary significantly increased (<i>p</i> &lt; 0.001 and <i>p</i> = 0.01, respectively) after treatment. Conclusions: OCTA showed VD increase in the papillary area in patients affected by CRVO after anti-VEGF therapy. This area could represent a new region of interest to study microvasculature changes concomitant with severe macular edema.
topic central retinal vein occlusions
anti-vegf
optical coherence tomography angiography
peripapillary vessel density
url https://www.mdpi.com/2077-0383/8/10/1636
work_keys_str_mv AT michelenicolai papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
AT alessandrofranceschi papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
AT serenadeturris papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
AT alessandrorosati papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
AT vittoriopirani papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
AT cesaremariotti papillaryvesseldensitychangesafterintravitrealantivegfinjectionsinhypertensivepatientswithcentralretinalveinocclusionanangiooctstudy
_version_ 1725858955960254464