Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling

Cardiac trabeculae (which are sponge-like muscular structures) form mostly as a result of cardiomyocyte (CM) delamination in zebrafish. Here, the authors identify Nrg2a in zebrafish as a key regulator of trabeculation, and atrial and non-contractile CMs also respond to Nrg2a despite not forming trab...

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Main Authors: S. Javad Rasouli, Didier Y. R. Stainier
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15281
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spelling doaj-311ce37c5db44cac88ab4718b4dabeb32021-05-11T07:54:52ZengNature Publishing GroupNature Communications2041-17232017-05-018111110.1038/ncomms15281Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signalingS. Javad Rasouli0Didier Y. R. Stainier1Department of Developmental Genetics, Max Planck Institute for Heart and Lung ResearchDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung ResearchCardiac trabeculae (which are sponge-like muscular structures) form mostly as a result of cardiomyocyte (CM) delamination in zebrafish. Here, the authors identify Nrg2a in zebrafish as a key regulator of trabeculation, and atrial and non-contractile CMs also respond to Nrg2a despite not forming trabeculae.https://doi.org/10.1038/ncomms15281
collection DOAJ
language English
format Article
sources DOAJ
author S. Javad Rasouli
Didier Y. R. Stainier
spellingShingle S. Javad Rasouli
Didier Y. R. Stainier
Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
Nature Communications
author_facet S. Javad Rasouli
Didier Y. R. Stainier
author_sort S. Javad Rasouli
title Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
title_short Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
title_full Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
title_fullStr Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
title_full_unstemmed Regulation of cardiomyocyte behavior in zebrafish trabeculation by Neuregulin 2a signaling
title_sort regulation of cardiomyocyte behavior in zebrafish trabeculation by neuregulin 2a signaling
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-05-01
description Cardiac trabeculae (which are sponge-like muscular structures) form mostly as a result of cardiomyocyte (CM) delamination in zebrafish. Here, the authors identify Nrg2a in zebrafish as a key regulator of trabeculation, and atrial and non-contractile CMs also respond to Nrg2a despite not forming trabeculae.
url https://doi.org/10.1038/ncomms15281
work_keys_str_mv AT sjavadrasouli regulationofcardiomyocytebehaviorinzebrafishtrabeculationbyneuregulin2asignaling
AT didieryrstainier regulationofcardiomyocytebehaviorinzebrafishtrabeculationbyneuregulin2asignaling
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