Detection and clinical significance of immune function, inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection

• Main Authors: Yu-Ling Zhang, Xiu-Shuang Zhang, Xiao-Zheng Meng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2018-08-01
• Series: Journal of Hainan Medical University
• Subjects: Mycoplasma pneumoniae; Immune function; Inflammatory factors; Erythrocyte sedimentation rate; Correlation analysis
• Online Access: http://www.hnykdxxb.com/PDF/201816/19.pdf

Objective: To explore the detection and clinical significance of immune function, inflammatory factors and ESR levels in children with Mycoplasma pneumoniae infection. Methods: A total of 122 children with Mycoplasma pneumoniae from September 2015 to February 2017 were selected as the observation group, while 120 healthy children were selected as the control group. The differences of immunoglobulin, T lymphocyte subsets, inflammatory factors and erythrocyte sedimentation rate (ESR) were compared in the two groups, and the correlation between ESR and inflammatory factors was analyzed. Results: There was a significant difference in peripheral blood T lymphocyte level between the two groups; CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly lower than those in the control group, while CD8+ was significantly higher in the observation group than in the control group. The IgA of the observation group was significantly lower than that of the control group, and there was no significant difference between IgG and the control group, and IgM was significantly higher than that of the control group. The two groups of hypersensitive C reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and ESR expression level were significant differences; the hs-CRP, TNF-α, IFN-γ and ESR in the observation group were significantly higher than those in the control group; the ESR of the children with mycoplasma pneumonia was positively correlated with the level of hs-CRP, TNF-α and IFN-γ, which was statistically significant. Conclusions: The cell immunity, humoral immune function of children with Mycoplasma pneumoniae infection are relatively low, and the inflammatory reaction is more severe, and the inflammatory factors of the body are positively related to the level of ESR expression.