A Review of Newly Diagnosed Glioblastoma

A Review of Newly Diagnosed Glioblastoma

Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomi...

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Bibliographic Details
Main Authors: Bryan Oronsky, Tony R. Reid, Arnold Oronsky, Navjot Sandhu, Susan J. Knox
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Oncology
Subjects:
glioblastoma
radiation therapy
high-grade gliomas
cancer
brain tumors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.574012/full
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spelling doaj-313115a120a844ef831e13fd574c20b72021-02-05T04:43:18ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-02-011010.3389/fonc.2020.574012574012A Review of Newly Diagnosed GlioblastomaBryan Oronsky0Tony R. Reid1Arnold Oronsky2Navjot Sandhu3Susan J. Knox4Department of Clinical Research, EpicentRx, San Diego, CA, United StatesDepartment of Medical Oncology, UC San Diego School of Medicine, San Diego, CA, United StatesDepartment of Clinical Research, InterWest Partners, Menlo Park, CA, United StatesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United StatesGlioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects.https://www.frontiersin.org/articles/10.3389/fonc.2020.574012/fullglioblastomaradiation therapyhigh-grade gliomascancerbrain tumors
collection DOAJ
language English
format Article
sources DOAJ
author Bryan Oronsky
Tony R. Reid
Arnold Oronsky
Navjot Sandhu
Susan J. Knox
spellingShingle Bryan Oronsky
Tony R. Reid
Arnold Oronsky
Navjot Sandhu
Susan J. Knox
A Review of Newly Diagnosed Glioblastoma
Frontiers in Oncology
glioblastoma
radiation therapy
high-grade gliomas
cancer
brain tumors
author_facet Bryan Oronsky
Tony R. Reid
Arnold Oronsky
Navjot Sandhu
Susan J. Knox
author_sort Bryan Oronsky
title A Review of Newly Diagnosed Glioblastoma
title_short A Review of Newly Diagnosed Glioblastoma
title_full A Review of Newly Diagnosed Glioblastoma
title_fullStr A Review of Newly Diagnosed Glioblastoma
title_full_unstemmed A Review of Newly Diagnosed Glioblastoma
title_sort review of newly diagnosed glioblastoma
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2021-02-01
description Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects.
topic glioblastoma
radiation therapy
high-grade gliomas
cancer
brain tumors
url https://www.frontiersin.org/articles/10.3389/fonc.2020.574012/full
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