Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.

Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans.

Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is expressed in all diabetes-relevant tissues and mediates cytokine-induced insulin resistance. We investigated whether common single nucleotide polymorphisms (SNPs) in the MAP4K4 locus associate with glucose intolerance, insulin resis...

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Bibliographic Details
Main Authors:	Tina Sartorius, Harald Staiger, Caroline Ketterer, Martin Heni, Fausto Machicao, Adilson Guilherme, Harald Grallert, Matthias B Schulze, Heiner Boeing, Norbert Stefan, Andreas Fritsche, Michael P Czech, Hans-Ulrich Häring
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3475716?pdf=render

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