Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation
Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06184-3 |
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doaj-314fcd580797451983c726cd599eaae12021-05-11T10:30:03ZengNature Publishing GroupNature Communications2041-17232018-09-019111710.1038/s41467-018-06184-3Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulationKatharina Essig0Nina Kronbeck1Joao C. Guimaraes2Claudia Lohs3Andreas Schlundt4Anne Hoffmann5Gesine Behrens6Sven Brenner7Joanna Kowalska8Cristina Lopez-Rodriguez9Jacek Jemielity10Helmut Holtmann11Kristin Reiche12Jörg Hackermüller13Michael Sattler14Mihaela Zavolan15Vigo Heissmeyer16Institute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenComputational and Systems Biology, Biozentrum, University of BaselResearch Unit Molecular Immune Regulation, Helmholtz Zentrum MünchenInstitute of Structural Biology, Helmholtz Zentrum MünchenYoung Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenResearch Unit Molecular Immune Regulation, Helmholtz Zentrum MünchenDivision of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of WarsawImmunology Unit, Department of Experimental and Health Sciences, Pompeu Fabra UniversityCentre of New Technologies, University of WarsawInstitute of Biochemistry, Hannover Medical SchoolYoung Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZYoung Investigators Group Bioinformatics and Transcriptomics, Department Molecular Systems Biology, Helmholtz Centre for Environmental Research—UFZInstitute of Structural Biology, Helmholtz Zentrum MünchenComputational and Systems Biology, Biozentrum, University of BaselInstitute for Immunology at the Biomedical Center, Ludwig-Maximilians-Universität MünchenRoquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs.https://doi.org/10.1038/s41467-018-06184-3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer |
| spellingShingle |
Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation Nature Communications |
| author_facet |
Katharina Essig Nina Kronbeck Joao C. Guimaraes Claudia Lohs Andreas Schlundt Anne Hoffmann Gesine Behrens Sven Brenner Joanna Kowalska Cristina Lopez-Rodriguez Jacek Jemielity Helmut Holtmann Kristin Reiche Jörg Hackermüller Michael Sattler Mihaela Zavolan Vigo Heissmeyer |
| author_sort |
Katharina Essig |
| title |
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation |
| title_short |
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation |
| title_full |
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation |
| title_fullStr |
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation |
| title_full_unstemmed |
Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation |
| title_sort |
roquin targets mrnas in a 3′-utr-specific manner by different modes of regulation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-09-01 |
| description |
Roquin targets are known to contain two types of sequence-structure motifs, the constitutive and the alternative decay elements (CDE and ADE). Here, the authors describe a linear Roquin binding element (LBE) also involved in target recognition, and show that Roquin binding affects the translation of a subset of targeted mRNAs. |
| url |
https://doi.org/10.1038/s41467-018-06184-3 |
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