Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies
Abstract Objective 18F‐FP‐CIT and 123I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with 123I‐FP‐CIT, 18F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using 18F‐FP‐CIT positron emission...
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doaj-31509f64394c49e5b10e0507e7be168a2021-05-02T19:09:49ZengWileyAnnals of Clinical and Translational Neurology2328-95032020-09-01791524153410.1002/acn3.51122Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studiesYanyan Kong0Chencheng Zhang1Kawai Liu2Aparna Wagle Shukla3Bomin Sun4Yihui Guan5Department of Neurosurgery, Center for Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025ChinaDepartment of Neurosurgery, Center for Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025ChinaDepartment of Mathematics The Shanghai SMIC Private School Shanghai 200000ChinaDepartment of Neurology and Fixel Center for Neurological Diseases and the Program for Movement Disorders and Neurorestoration University of Florida Gainesville FL 32611Department of Neurosurgery, Center for Functional Neurosurgery Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025ChinaPET Center Huashan Hospital Fudan University Shanghai 200235ChinaAbstract Objective 18F‐FP‐CIT and 123I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with 123I‐FP‐CIT, 18F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using 18F‐FP‐CIT positron emission tomography (PET) and 123I‐FP‐CIT single‐photon emission computed tomography (SPECT) of dopamine transporters in patients with PD in order to provide evidence for clinical decision‐making. Methods We searched the PubMed, Embase, Wanfang Data, and China National Knowledge Infrastructure databases to identify the relevant studies from the time of inception of the databases to 30 April 2020. We identified six PET studies, including 779 patients with PD and 124 healthy controls, which met the inclusion criteria. Twenty‐seven SPECT studies with 1244 PD patients and 859 controls were also included in this meta‐analysis. Results Overall effect‐size analysis indicated that patients with PD showed significantly reduced 18F‐FP‐CIT uptake in three brain regions [caudate nucleus: standardized mean difference (SMD) = −1.71, Z = −3.31, P = 0.0009; anterior putamen: SMD = −3.71, Z = −6.26, P < 0.0001; and posterior putamen: SMD = −5.49, Z = −5.97, P < 0.0001]. Significant decreases of 123I‐FP‐CIT uptake were also observed in the caudate (SMD = −2.31, Z = −11.49, P < 0.0001) and putamen (SMD = −3.25, Z = −14.79, P < 0.0001). Interpretation In conclusion, our findings indicate that both 18F‐FP‐CIT PET and 123I‐FP‐CIT SPECT imaging of dopamine transporters can provide viable biomarkers for early PD diagnosis.https://doi.org/10.1002/acn3.51122 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yanyan Kong Chencheng Zhang Kawai Liu Aparna Wagle Shukla Bomin Sun Yihui Guan |
spellingShingle |
Yanyan Kong Chencheng Zhang Kawai Liu Aparna Wagle Shukla Bomin Sun Yihui Guan Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies Annals of Clinical and Translational Neurology |
author_facet |
Yanyan Kong Chencheng Zhang Kawai Liu Aparna Wagle Shukla Bomin Sun Yihui Guan |
author_sort |
Yanyan Kong |
title |
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies |
title_short |
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies |
title_full |
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies |
title_fullStr |
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies |
title_full_unstemmed |
Imaging of dopamine transporters in Parkinson disease: a meta‐analysis of 18F/123I‐FP‐CIT studies |
title_sort |
imaging of dopamine transporters in parkinson disease: a meta‐analysis of 18f/123i‐fp‐cit studies |
publisher |
Wiley |
series |
Annals of Clinical and Translational Neurology |
issn |
2328-9503 |
publishDate |
2020-09-01 |
description |
Abstract Objective 18F‐FP‐CIT and 123I‐FP‐CIT are widely used radiotracers in molecular imaging for Parkinson’s disease (PD) diagnosis. Compared with 123I‐FP‐CIT, 18F‐FP‐CIT has superior tracer kinetics. We aimed to conduct a meta‐analysis to assess the efficacy of using 18F‐FP‐CIT positron emission tomography (PET) and 123I‐FP‐CIT single‐photon emission computed tomography (SPECT) of dopamine transporters in patients with PD in order to provide evidence for clinical decision‐making. Methods We searched the PubMed, Embase, Wanfang Data, and China National Knowledge Infrastructure databases to identify the relevant studies from the time of inception of the databases to 30 April 2020. We identified six PET studies, including 779 patients with PD and 124 healthy controls, which met the inclusion criteria. Twenty‐seven SPECT studies with 1244 PD patients and 859 controls were also included in this meta‐analysis. Results Overall effect‐size analysis indicated that patients with PD showed significantly reduced 18F‐FP‐CIT uptake in three brain regions [caudate nucleus: standardized mean difference (SMD) = −1.71, Z = −3.31, P = 0.0009; anterior putamen: SMD = −3.71, Z = −6.26, P < 0.0001; and posterior putamen: SMD = −5.49, Z = −5.97, P < 0.0001]. Significant decreases of 123I‐FP‐CIT uptake were also observed in the caudate (SMD = −2.31, Z = −11.49, P < 0.0001) and putamen (SMD = −3.25, Z = −14.79, P < 0.0001). Interpretation In conclusion, our findings indicate that both 18F‐FP‐CIT PET and 123I‐FP‐CIT SPECT imaging of dopamine transporters can provide viable biomarkers for early PD diagnosis. |
url |
https://doi.org/10.1002/acn3.51122 |
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