HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.
The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity. Th...
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doaj-3156ea50d2cd4270adfcfed6593d7e332020-11-25T00:27:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015083510.1371/journal.pone.0150835HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity.Michael R NonnemacherVanessa PirroneRui FengBrian MoldoverShendra PassicBenjamas AiamkitsumritWill DampierAdam WojnoEvelyn KilareskiBrandon BlakeyTse-Sheun Jade KuSonia ShahNeil T SullivanJeffrey M JacobsonBrian WigdahlThe large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity. This study presents a cross-sectional/longitudinal study of HIV-1 single nucleotide polymorphisms (SNPs) contained within the viral promoter or long terminal repeat (LTR) in patients within the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. HIV-1 LTR SNPs were found to associate with the classical clinical disease parameters CD4+ T-cell count and log viral load. They were found in both defined and undefined transcription factor binding sites of the LTR. A novel SNP identified at position 108 in a known COUP (chicken ovalbumin upstream promoter)/AP1 transcription factor binding site was significantly correlated with binding phenotypes that are potentially the underlying cause of the associated clinical outcome (increase in viral load and decrease in CD4+ T-cell count).http://europepmc.org/articles/PMC4839606?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael R Nonnemacher Vanessa Pirrone Rui Feng Brian Moldover Shendra Passic Benjamas Aiamkitsumrit Will Dampier Adam Wojno Evelyn Kilareski Brandon Blakey Tse-Sheun Jade Ku Sonia Shah Neil T Sullivan Jeffrey M Jacobson Brian Wigdahl |
spellingShingle |
Michael R Nonnemacher Vanessa Pirrone Rui Feng Brian Moldover Shendra Passic Benjamas Aiamkitsumrit Will Dampier Adam Wojno Evelyn Kilareski Brandon Blakey Tse-Sheun Jade Ku Sonia Shah Neil T Sullivan Jeffrey M Jacobson Brian Wigdahl HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. PLoS ONE |
author_facet |
Michael R Nonnemacher Vanessa Pirrone Rui Feng Brian Moldover Shendra Passic Benjamas Aiamkitsumrit Will Dampier Adam Wojno Evelyn Kilareski Brandon Blakey Tse-Sheun Jade Ku Sonia Shah Neil T Sullivan Jeffrey M Jacobson Brian Wigdahl |
author_sort |
Michael R Nonnemacher |
title |
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. |
title_short |
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. |
title_full |
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. |
title_fullStr |
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. |
title_full_unstemmed |
HIV-1 Promoter Single Nucleotide Polymorphisms Are Associated with Clinical Disease Severity. |
title_sort |
hiv-1 promoter single nucleotide polymorphisms are associated with clinical disease severity. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
The large majority of human immunodeficiency virus type 1 (HIV-1) markers of disease progression/severity previously identified have been associated with alterations in host genetic and immune responses, with few studies focused on viral genetic markers correlate with changes in disease severity. This study presents a cross-sectional/longitudinal study of HIV-1 single nucleotide polymorphisms (SNPs) contained within the viral promoter or long terminal repeat (LTR) in patients within the Drexel Medicine CNS AIDS Research and Eradication Study (CARES) Cohort. HIV-1 LTR SNPs were found to associate with the classical clinical disease parameters CD4+ T-cell count and log viral load. They were found in both defined and undefined transcription factor binding sites of the LTR. A novel SNP identified at position 108 in a known COUP (chicken ovalbumin upstream promoter)/AP1 transcription factor binding site was significantly correlated with binding phenotypes that are potentially the underlying cause of the associated clinical outcome (increase in viral load and decrease in CD4+ T-cell count). |
url |
http://europepmc.org/articles/PMC4839606?pdf=render |
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