A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer
Aim: The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival of ovarian cancer patients with liver metastases upon initial diagnosis.Methods: Patients with ovarian cancer liver metastases upon initial diagnosis between 2010 and 2016 were iden...
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Frontiers Media S.A.
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doaj-315d9375a2764812ae27a6b49ea96f272020-11-25T03:14:02ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.571671571671A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian CancerHaiyun Zhao0Haiyun Zhao1Fei Xu2Fei Xu3Jiajia Li4Mengdong Ni5Xiaohua Wu6Xiaohua Wu7Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, ChinaDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, ChinaAim: The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival of ovarian cancer patients with liver metastases upon initial diagnosis.Methods: Patients with ovarian cancer liver metastases upon initial diagnosis between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression was performed to identify the predictors of the presence of liver metastases in newly diagnosed ovarian cancer patients. Overall survival (OS) was assessed using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression was conducted to determine the independent prognostic factors for OS.Results: A total of 1,744 ovarian cancer patients with liver metastases was identified from the SEER database, accounting for 6.7% of the entire ovarian cancer patients. As to the unique distant organ provided by SEER, liver was the most common metastatic site of ovarian cancer (4.65%). Age, race, laterality, histology, pathological grade, extrahepatic sites, stage of tumor were the predictors of the presence with liver metastases revealed by multivariable logistic regression model. Median OS for the patients with liver metastases at initial diagnosis of ovarian cancer was 16.0 months. Multivariate Cox regression model confirmed race, histology, extrahepatic metastatic sites, surgery and marital status were independent prognostic factors for OS.Conclusion: The study provided population-based estimates of the incidence and prognosis of newly diagnosed ovary cancer patients with liver metastases, which could be potentially used for the risk assessment and individualized treatment.https://www.frontiersin.org/article/10.3389/fonc.2020.571671/fullliver metastasesovarian cancerincidenceprognosisSEER |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Haiyun Zhao Haiyun Zhao Fei Xu Fei Xu Jiajia Li Mengdong Ni Xiaohua Wu Xiaohua Wu |
spellingShingle |
Haiyun Zhao Haiyun Zhao Fei Xu Fei Xu Jiajia Li Mengdong Ni Xiaohua Wu Xiaohua Wu A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer Frontiers in Oncology liver metastases ovarian cancer incidence prognosis SEER |
author_facet |
Haiyun Zhao Haiyun Zhao Fei Xu Fei Xu Jiajia Li Mengdong Ni Xiaohua Wu Xiaohua Wu |
author_sort |
Haiyun Zhao |
title |
A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer |
title_short |
A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer |
title_full |
A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer |
title_fullStr |
A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer |
title_full_unstemmed |
A Population-Based Study on Liver Metastases in Women With Newly Diagnosed Ovarian Cancer |
title_sort |
population-based study on liver metastases in women with newly diagnosed ovarian cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-09-01 |
description |
Aim: The purpose of this study was to analyze the incidence, clinical characteristics, prognostic factors and survival of ovarian cancer patients with liver metastases upon initial diagnosis.Methods: Patients with ovarian cancer liver metastases upon initial diagnosis between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate logistic regression was performed to identify the predictors of the presence of liver metastases in newly diagnosed ovarian cancer patients. Overall survival (OS) was assessed using the Kaplan-Meier method and log-rank test. Univariate and multivariate Cox regression was conducted to determine the independent prognostic factors for OS.Results: A total of 1,744 ovarian cancer patients with liver metastases was identified from the SEER database, accounting for 6.7% of the entire ovarian cancer patients. As to the unique distant organ provided by SEER, liver was the most common metastatic site of ovarian cancer (4.65%). Age, race, laterality, histology, pathological grade, extrahepatic sites, stage of tumor were the predictors of the presence with liver metastases revealed by multivariable logistic regression model. Median OS for the patients with liver metastases at initial diagnosis of ovarian cancer was 16.0 months. Multivariate Cox regression model confirmed race, histology, extrahepatic metastatic sites, surgery and marital status were independent prognostic factors for OS.Conclusion: The study provided population-based estimates of the incidence and prognosis of newly diagnosed ovary cancer patients with liver metastases, which could be potentially used for the risk assessment and individualized treatment. |
topic |
liver metastases ovarian cancer incidence prognosis SEER |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.571671/full |
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