Control of plant cell fate transitions by transcriptional and hormonal signals
Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differ...
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doaj-31607e393af0436e9d2a7249f6f6d9002021-05-05T13:52:56ZengeLife Sciences Publications LtdeLife2050-084X2017-10-01610.7554/eLife.30135Control of plant cell fate transitions by transcriptional and hormonal signalsChristophe Gaillochet0https://orcid.org/0000-0003-0537-1356Thomas Stiehl1https://orcid.org/0000-0001-9686-9197Christian Wenzl2Juan-José Ripoll3https://orcid.org/0000-0002-8229-1555Lindsay J Bailey-Steinitz4Lanxin Li5Anne Pfeiffer6https://orcid.org/0000-0001-6825-6297Andrej Miotk7https://orcid.org/0000-0003-2581-672XJana P Hakenjos8Joachim Forner9https://orcid.org/0000-0002-6406-7066Martin F Yanofsky10Anna Marciniak-Czochra11https://orcid.org/0000-0002-5831-6505Jan U Lohmann12https://orcid.org/0000-0003-3667-187XDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyInstitute of Applied Mathematics, Heidelberg University, Heidelberg, Germany; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, San Diego, United StatesDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, San Diego, United StatesDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyDivision of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, San Diego, United StatesInstitute of Applied Mathematics, Heidelberg University, Heidelberg, Germany; Interdisciplinary Center for Scientific Computing, Heidelberg University, Heidelberg, Germany; Bioquant Center, Heidelberg University, Heidelberg, GermanyDepartment of Stem Cell Biology, Centre for Organismal Studies, University of Heidelberg, Heidelberg, GermanyPlant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors transcriptionally control and physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the autocatalytic stabilization of auxin signalling output.https://elifesciences.org/articles/30135HECATE1auxincytokininshoot meristemcell fate |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christophe Gaillochet Thomas Stiehl Christian Wenzl Juan-José Ripoll Lindsay J Bailey-Steinitz Lanxin Li Anne Pfeiffer Andrej Miotk Jana P Hakenjos Joachim Forner Martin F Yanofsky Anna Marciniak-Czochra Jan U Lohmann |
spellingShingle |
Christophe Gaillochet Thomas Stiehl Christian Wenzl Juan-José Ripoll Lindsay J Bailey-Steinitz Lanxin Li Anne Pfeiffer Andrej Miotk Jana P Hakenjos Joachim Forner Martin F Yanofsky Anna Marciniak-Czochra Jan U Lohmann Control of plant cell fate transitions by transcriptional and hormonal signals eLife HECATE1 auxin cytokinin shoot meristem cell fate |
author_facet |
Christophe Gaillochet Thomas Stiehl Christian Wenzl Juan-José Ripoll Lindsay J Bailey-Steinitz Lanxin Li Anne Pfeiffer Andrej Miotk Jana P Hakenjos Joachim Forner Martin F Yanofsky Anna Marciniak-Czochra Jan U Lohmann |
author_sort |
Christophe Gaillochet |
title |
Control of plant cell fate transitions by transcriptional and hormonal signals |
title_short |
Control of plant cell fate transitions by transcriptional and hormonal signals |
title_full |
Control of plant cell fate transitions by transcriptional and hormonal signals |
title_fullStr |
Control of plant cell fate transitions by transcriptional and hormonal signals |
title_full_unstemmed |
Control of plant cell fate transitions by transcriptional and hormonal signals |
title_sort |
control of plant cell fate transitions by transcriptional and hormonal signals |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2017-10-01 |
description |
Plant meristems carry pools of continuously active stem cells, whose activity is controlled by developmental and environmental signals. After stem cell division, daughter cells that exit the stem cell domain acquire transit amplifying cell identity before they are incorporated into organs and differentiate. In this study, we used an integrated approach to elucidate the role of HECATE (HEC) genes in regulating developmental trajectories of shoot stem cells in Arabidopsis thaliana. Our work reveals that HEC function stabilizes cell fate in distinct zones of the shoot meristem thereby controlling the spatio-temporal dynamics of stem cell differentiation. Importantly, this activity is concomitant with the local modulation of cellular responses to cytokinin and auxin, two key phytohormones regulating cell behaviour. Mechanistically, we show that HEC factors transcriptionally control and physically interact with MONOPTEROS (MP), a key regulator of auxin signalling, and modulate the autocatalytic stabilization of auxin signalling output. |
topic |
HECATE1 auxin cytokinin shoot meristem cell fate |
url |
https://elifesciences.org/articles/30135 |
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