The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers

MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, a...

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Main Authors: Leila Jahangiri, Perla Pucci, Tala Ishola, Ricky M. Trigg, John A. Williams, Joao Pereira, Megan L. Cavanagh, Suzanne D. Turner, Georgios V. Gkoutos, Loukia Tsaprouni
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
MYC
gene regulatory networks (GRNs)
autophagy
lncRNAs
Online Access:https://www.mdpi.com/1422-0067/22/16/8527
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spelling doaj-316377926a4a442eb0b305705449aaeb2021-08-26T13:51:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01228527852710.3390/ijms22168527The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in CancersLeila Jahangiri0Perla Pucci1Tala Ishola2Ricky M. Trigg3John A. Williams4Joao Pereira5Megan L. Cavanagh6Suzanne D. Turner7Georgios V. Gkoutos8Loukia Tsaprouni9Department of Life Sciences, Birmingham City University, Birmingham B15 3TN, UKDivision of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UKDepartment of Life Sciences, Birmingham City University, Birmingham B15 3TN, UKDepartment of Functional Genomics, GlaxoSmithKline, Stevenage SG1 2NY, UKInstitute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UKDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USADepartment of Life Sciences, Birmingham City University, Birmingham B15 3TN, UKDivision of Cellular and Molecular Pathology, Department of Pathology, University of Cambridge, Cambridge CB2 0QQ, UKInstitute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, UKDepartment of Life Sciences, Birmingham City University, Birmingham B15 3TN, UKMYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.https://www.mdpi.com/1422-0067/22/16/8527MYCgene regulatory networks (GRNs)autophagylncRNAs
collection DOAJ
language English
format Article
sources DOAJ
author Leila Jahangiri
Perla Pucci
Tala Ishola
Ricky M. Trigg
John A. Williams
Joao Pereira
Megan L. Cavanagh
Suzanne D. Turner
Georgios V. Gkoutos
Loukia Tsaprouni
spellingShingle Leila Jahangiri
Perla Pucci
Tala Ishola
Ricky M. Trigg
John A. Williams
Joao Pereira
Megan L. Cavanagh
Suzanne D. Turner
Georgios V. Gkoutos
Loukia Tsaprouni
The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
International Journal of Molecular Sciences
MYC
gene regulatory networks (GRNs)
autophagy
lncRNAs
author_facet Leila Jahangiri
Perla Pucci
Tala Ishola
Ricky M. Trigg
John A. Williams
Joao Pereira
Megan L. Cavanagh
Suzanne D. Turner
Georgios V. Gkoutos
Loukia Tsaprouni
author_sort Leila Jahangiri
title The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
title_short The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
title_full The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
title_fullStr The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
title_full_unstemmed The Contribution of Autophagy and LncRNAs to MYC-Driven Gene Regulatory Networks in Cancers
title_sort contribution of autophagy and lncrnas to myc-driven gene regulatory networks in cancers
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-08-01
description MYC is a target of the Wnt signalling pathway and governs numerous cellular and developmental programmes hijacked in cancers. The amplification of MYC is a frequently occurring genetic alteration in cancer genomes, and this transcription factor is implicated in metabolic reprogramming, cell death, and angiogenesis in cancers. In this review, we analyse MYC gene networks in solid cancers. We investigate the interaction of MYC with long non-coding RNAs (lncRNAs). Furthermore, we investigate the role of MYC regulatory networks in inducing changes to cellular processes, including autophagy and mitophagy. Finally, we review the interaction and mutual regulation between MYC and lncRNAs, and autophagic processes and analyse these networks as unexplored areas of targeting and manipulation for therapeutic gain in MYC-driven malignancies.
topic MYC
gene regulatory networks (GRNs)
autophagy
lncRNAs
url https://www.mdpi.com/1422-0067/22/16/8527
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