Apoptotic functions of microRNAs in pathogenesis, diagnosis, and treatment of endometriosis

• Main Authors: Mona Taghavipour, Fatemeh Sadoughi, Hamed Mirzaei, Bahman Yousefi, Bahram Moazzami, Shahla Chaichian, Mohammad Ali Mansournia, Zatollah Asemi
• Format: Article
• Language: English
• Published: BMC 2020-02-01
• Series: Cell & Bioscience
• Subjects: Apoptosis; miRNA; Endometriosis; BCL-2; BAX
• Online Access: https://doi.org/10.1186/s13578-020-0381-0

Abstract MicroRNAs or miRNAs are a component of the non-coding RNAs family which is engaged in many cellular functions such as cell proliferation, apoptosis, gene expression, signaling pathways, angiogenesis, and etc. Endometriosis is a malignant gynecologic disorder occurring in women before menopausal age. Pathogenesis of this illness is still a discussion subject between the scientists but in our knowledge, microRNAs can be one of the possible involved factors. The purpose of this paper is to investigate the role of apoptotic activities of miRNAs in endometriosis. Accumulative evidence has demonstrated the role of cell proliferation, apoptosis, and invasion in the progression of these diseases. In this review, we looked into the specific role of apoptosis and its related genes and pathways in endometriosis and tied to present an explanation of how miRNAs can affect endometriosis by their apoptotic activities. What we found is that a great extent of miRNAs is involved in this illness and they are responsible for repressing apoptosis and progression of the disease. As a result, miRNAs have two different usages in endometriosis: biomarkers and potential therapeutic targets. In this review we gathered a great amount of evidence to inquire into the role of micro RNAs in inducing apoptosis and how this mechanism can be exerted for therapeutic purposes for endometriosis.