Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Therapeutics: Helping vesicles to deliver drugs inside cells An increased understanding of how extracellular vesicles (EVs) enter cells and deliver molecules will enable promising new therapies, according to researchers in the Netherlands, UK and France. EVs are liquid-filled sacs secreted by cells...
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2019-03-01
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doaj-316df075eed04434ba364fbd33b3895c2020-12-08T13:49:25ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-03-0151311210.1038/s12276-019-0223-5Extracellular vesicle-based therapeutics: natural versus engineered targeting and traffickingDaniel E. Murphy0Olivier G. de Jong1Maarten Brouwer2Matthew J. Wood3Grégory Lavieu4Raymond M. Schiffelers5Pieter Vader6Laboratory of Clinical Chemistry and Haematology, UMC UtrechtLaboratory of Clinical Chemistry and Haematology, UMC UtrechtLaboratory of Clinical Chemistry and Haematology, UMC UtrechtDepartment of Physiology, Anatomy and Genetics, University of OxfordInstitut Curie, PSL Research UniversityLaboratory of Clinical Chemistry and Haematology, UMC UtrechtLaboratory of Clinical Chemistry and Haematology, UMC UtrechtTherapeutics: Helping vesicles to deliver drugs inside cells An increased understanding of how extracellular vesicles (EVs) enter cells and deliver molecules will enable promising new therapies, according to researchers in the Netherlands, UK and France. EVs are liquid-filled sacs secreted by cells that transport proteins, lipids and RNA between cells, and therefore have potential for delivering drugs. Pieter Vader at UMC Utrecht and co-workers review recent research into EVs, focusing on how EVs are distributed around the body, and how they target and enter cells. However, there is little known about EV biology once they are inside cells, and it is likely that many EVs simply degrade without delivering their cargo. Further research in this area could help identify features that improve cargo escape from EVs, thus ensuring that future therapies can be effective.https://doi.org/10.1038/s12276-019-0223-5 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniel E. Murphy Olivier G. de Jong Maarten Brouwer Matthew J. Wood Grégory Lavieu Raymond M. Schiffelers Pieter Vader |
spellingShingle |
Daniel E. Murphy Olivier G. de Jong Maarten Brouwer Matthew J. Wood Grégory Lavieu Raymond M. Schiffelers Pieter Vader Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking Experimental and Molecular Medicine |
author_facet |
Daniel E. Murphy Olivier G. de Jong Maarten Brouwer Matthew J. Wood Grégory Lavieu Raymond M. Schiffelers Pieter Vader |
author_sort |
Daniel E. Murphy |
title |
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
title_short |
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
title_full |
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
title_fullStr |
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
title_full_unstemmed |
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
title_sort |
extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2019-03-01 |
description |
Therapeutics: Helping vesicles to deliver drugs inside cells An increased understanding of how extracellular vesicles (EVs) enter cells and deliver molecules will enable promising new therapies, according to researchers in the Netherlands, UK and France. EVs are liquid-filled sacs secreted by cells that transport proteins, lipids and RNA between cells, and therefore have potential for delivering drugs. Pieter Vader at UMC Utrecht and co-workers review recent research into EVs, focusing on how EVs are distributed around the body, and how they target and enter cells. However, there is little known about EV biology once they are inside cells, and it is likely that many EVs simply degrade without delivering their cargo. Further research in this area could help identify features that improve cargo escape from EVs, thus ensuring that future therapies can be effective. |
url |
https://doi.org/10.1038/s12276-019-0223-5 |
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