The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer
The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system clearly plays a special role. Indeed, the breakdown of the physiological balance in gut microbial composition leads to dysbiosis, which is then...
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doaj-31760221e1c549c0a536f76dedeb0c0c2020-11-24T20:44:28ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120350110.3390/ijms20030501ijms20030501The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of CancerRossella Cianci0Laura Franza1Giovanni Schinzari2Ernesto Rossi3Gianluca Ianiro4Giampaolo Tortora5Antonio Gasbarrini6Giovanni Gambassi7Giovanni Cammarota8Department of Internal Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyDepartment of Internal Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyDepartment of Medical Oncology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy, <email>giovanni.schinzari@unicatt.it</email> (G.S.)Department of Medical Oncology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy, <email>giovanni.schinzari@unicatt.it</email> (G.S.)Department of Gastroenterology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyDepartment of Medical Oncology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, Italy, <email>giovanni.schinzari@unicatt.it</email> (G.S.)Department of Gastroenterology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyDepartment of Internal Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyDepartment of Gastroenterology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168 Roma, ItalyThe gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system clearly plays a special role. Indeed, the breakdown of the physiological balance in gut microbial composition leads to dysbiosis, which is then able to enhance inflammation and to influence gene expression. At the same time, there is an intense cross-talk between the microbiota and the immunological niche in the intestinal mucosa. These interactions may pave the way to the development, growth and spreading of cancer, especially in the gastro-intestinal system. Here, we review the changes in microbiota composition, how they relate to the immunological imbalance, influencing the onset of different types of cancer and the impact of these mechanisms on the efficacy of traditional and upcoming cancer treatments.https://www.mdpi.com/1422-0067/20/3/501gut microbiotaimmunological nichedysbiosiscancerimmune system |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rossella Cianci Laura Franza Giovanni Schinzari Ernesto Rossi Gianluca Ianiro Giampaolo Tortora Antonio Gasbarrini Giovanni Gambassi Giovanni Cammarota |
spellingShingle |
Rossella Cianci Laura Franza Giovanni Schinzari Ernesto Rossi Gianluca Ianiro Giampaolo Tortora Antonio Gasbarrini Giovanni Gambassi Giovanni Cammarota The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer International Journal of Molecular Sciences gut microbiota immunological niche dysbiosis cancer immune system |
author_facet |
Rossella Cianci Laura Franza Giovanni Schinzari Ernesto Rossi Gianluca Ianiro Giampaolo Tortora Antonio Gasbarrini Giovanni Gambassi Giovanni Cammarota |
author_sort |
Rossella Cianci |
title |
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer |
title_short |
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer |
title_full |
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer |
title_fullStr |
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer |
title_full_unstemmed |
The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer |
title_sort |
interplay between immunity and microbiota at intestinal immunological niche: the case of cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-01-01 |
description |
The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system clearly plays a special role. Indeed, the breakdown of the physiological balance in gut microbial composition leads to dysbiosis, which is then able to enhance inflammation and to influence gene expression. At the same time, there is an intense cross-talk between the microbiota and the immunological niche in the intestinal mucosa. These interactions may pave the way to the development, growth and spreading of cancer, especially in the gastro-intestinal system. Here, we review the changes in microbiota composition, how they relate to the immunological imbalance, influencing the onset of different types of cancer and the impact of these mechanisms on the efficacy of traditional and upcoming cancer treatments. |
topic |
gut microbiota immunological niche dysbiosis cancer immune system |
url |
https://www.mdpi.com/1422-0067/20/3/501 |
work_keys_str_mv |
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