Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

Anti-inflammatory effect of a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor via the stimulation of heme oxygenase-1 in LPS-activated mice and J774.1 murine macrophages

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone to the active cortisol. 11β-HSD1 may be involved in the resolution of inflammation. In the present study, we investigate the anti-inflammatory effects of 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-pheny...

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Bibliographic Details
Main Authors: Sung Bum Park, Ji Seon Park, Won Hoon Jung, Hee Youn Kim, Hyun Jung Kwak, Jin Hee Ahn, Kyoung-Jin Choi, Yoon-Ju Na, Sunhwa Choi, Sang Dal Rhee, Ki Young Kim
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Pharmacological Sciences
Subjects:
11β-Hydroxysteroid dehydrogenase type 1
Heme oxygenase-1
Lipopolysaccharide
Anti-inflammatory effect
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300858

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http://www.sciencedirect.com/science/article/pii/S1347861316300858

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