Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population

• Main Authors: Yipeng Ding, Hua Yang, Haiwu He, Huifang Shi, Ping He, Shouchun Yan, Tianbo Jin
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2015-10-01
• Series: Iranian Journal of Allergy, Asthma and Immunology
• Subjects: Adiponectin; Asthma; Case-control studies
• Online Access: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/570

The purpose of this study was to determine the clinical significance of changes in the plasma  adiponectin  concentration  in  patients  with  bronchial  asthma  and  to  test  the association between the single nucleotide polymorphisms (SNPs) rs2241766 and rs1501299 in the ADIPOQ gene and bronchial asthma in the Chinese Li population.We selected 120 cases and 120 controls, and plasma adiponectin, interleukin (IL)-6, and tumor  necrosis  factor-alpha  (TNF-α)  levels  were  measured  by  enzyme-linked immunosorbent assay (ELISA). In addition, we genotyped two tag single nucleotide polymorphisms (tSNPs) and evaluated their association with bronchial asthma using the χ2 test and genetic model analysis.Compared to controls, patients with acute exacerbation of bronchial asthma showedsignificantly lower adiponectin and significantly higher IL-6 and TNF-α levels (p<0.01). Apositive association was found between the rs1501299 SNP and acute exacerbation (OR =1.62; 95% CI= 1.08-2.43; p= 0.019).The inverse correlation between the plasma adiponectin concentration and asthma exacerbation indicates that adiponectin may play a protective role in the pathogenesis of asthma. Meanwhile, our findings suggest that ADIPOQ polymorphisms influence the risk of developing bronchial asthma in Chinese Li population.