Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice
The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative colitis was examined. Experimental colitis was induced in mice by administering 5% dextran sulphate sodium (DSS). SDG in doses of 100 and 200 mg/kg/day and 5-aminosalicylic acid (positive control) were given orally fo...
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Format: | Article |
Language: | English |
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Elsevier
2016-10-01
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Series: | Journal of Functional Foods |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S175646461630192X |
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doaj-31798a03769948568378f7806c30e92c |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiqu Xu Guangjing Tian Congcong Ma Hui Gao Chang Chen Wei Yang Qianchun Deng Qingde Huang Zhonghua Ma Fenghong Huang |
spellingShingle |
Jiqu Xu Guangjing Tian Congcong Ma Hui Gao Chang Chen Wei Yang Qianchun Deng Qingde Huang Zhonghua Ma Fenghong Huang Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice Journal of Functional Foods Secoisolariciresinol diglucoside Ulcerative colitis Dextran sulphate sodium Inflammation Mucosal permeability |
author_facet |
Jiqu Xu Guangjing Tian Congcong Ma Hui Gao Chang Chen Wei Yang Qianchun Deng Qingde Huang Zhonghua Ma Fenghong Huang |
author_sort |
Jiqu Xu |
title |
Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
title_short |
Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
title_full |
Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
title_fullStr |
Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
title_full_unstemmed |
Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
title_sort |
flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2016-10-01 |
description |
The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative colitis was examined. Experimental colitis was induced in mice by administering 5% dextran sulphate sodium (DSS). SDG in doses of 100 and 200 mg/kg/day and 5-aminosalicylic acid (positive control) were given orally for 3 days before and during DSS administration. Oral SDG treatment significantly decreased the disease activity index and increased colon length. Histological examination revealed that the oral administration of SDG suppressed DSS-induced erosion, ulceration, crypt abscesses and oedema. Furthermore, colonic myeloperoxidase activity and TNF-α expression declined remarkably following treatment with SDG. Additionally, oral SDG treatment significantly increased the expression of several mucoprotection markers, to include zona occludens-1, Tollip and trefoil factor 3, and thus restored intestinal permeability. These results suggested that oral SDG treatment can alleviate DSS-induced colitis and might be a promising supplement for the amelioration of inflammatory bowel disease. |
topic |
Secoisolariciresinol diglucoside Ulcerative colitis Dextran sulphate sodium Inflammation Mucosal permeability |
url |
http://www.sciencedirect.com/science/article/pii/S175646461630192X |
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doaj-31798a03769948568378f7806c30e92c2021-04-30T07:08:19ZengElsevierJournal of Functional Foods1756-46462016-10-0126187195Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in miceJiqu Xu0Guangjing Tian1Congcong Ma2Hui Gao3Chang Chen4Wei Yang5Qianchun Deng6Qingde Huang7Zhonghua Ma8Fenghong Huang9Department of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, ChinaDepartment of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, ChinaDepartment of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, ChinaDepartment of Gastroenterology, The First People's Hospital of Yichang, The People's Hospital of China Three Gorges University, 2 Jiefang Road, Yichang 443000, China; Department of Gastroenterology, The People's Hospital of China Three Gorges University, 2 Jiefang Road, Yichang 443000, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, ChinaDepartment of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, ChinaDepartment of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, ChinaFunctional Oil Laboratory Associated by Oil Crops Research Institute, Chinese Academy of Agricultural Sciences and Infinite (China) Co., LTD., 66 Jianzhong Road, Guangzhou 510665, ChinaDepartment of Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Hubei Key Laboratory of Lipid Chemistry and Nutrition, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China; Corresponding author. Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, China. Fax: +86 027 86815916.The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative colitis was examined. Experimental colitis was induced in mice by administering 5% dextran sulphate sodium (DSS). SDG in doses of 100 and 200 mg/kg/day and 5-aminosalicylic acid (positive control) were given orally for 3 days before and during DSS administration. Oral SDG treatment significantly decreased the disease activity index and increased colon length. Histological examination revealed that the oral administration of SDG suppressed DSS-induced erosion, ulceration, crypt abscesses and oedema. Furthermore, colonic myeloperoxidase activity and TNF-α expression declined remarkably following treatment with SDG. Additionally, oral SDG treatment significantly increased the expression of several mucoprotection markers, to include zona occludens-1, Tollip and trefoil factor 3, and thus restored intestinal permeability. These results suggested that oral SDG treatment can alleviate DSS-induced colitis and might be a promising supplement for the amelioration of inflammatory bowel disease.http://www.sciencedirect.com/science/article/pii/S175646461630192XSecoisolariciresinol diglucosideUlcerative colitisDextran sulphate sodiumInflammationMucosal permeability |