Microneedle-Based Delivery: An Overview of Current Applications and Trends
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the <i>stratum</i> <i>corneum</i>, overcoming the potential...
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doaj-3186afdad1074e24bf84f765f2b5ad022020-11-25T03:04:46ZengMDPI AGPharmaceutics1999-49232020-06-011256956910.3390/pharmaceutics12060569Microneedle-Based Delivery: An Overview of Current Applications and TrendsAntonio José Guillot0Ana Sara Cordeiro1Ryan F. Donnelly2M. Carmen Montesinos3Teresa M. Garrigues4Ana Melero5Department of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Avda. Vincent Andrés Estellés s/n, 46100 Burjassot, SpainSchool of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UKSchool of Pharmacy, Queen’s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UKDepartment of Pharmacology, Faculty of Pharmacy, University of Valencia, Avda. Vincent Andrés Estellés s/n, 46100 Burjassot, SpainDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Avda. Vincent Andrés Estellés s/n, 46100 Burjassot, SpainDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, Faculty of Pharmacy, University of Valencia, Avda. Vincent Andrés Estellés s/n, 46100 Burjassot, SpainMicroneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the <i>stratum</i> <i>corneum</i>, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed.https://www.mdpi.com/1999-4923/12/6/569microneedlesmicroneedle arraytransdermal deliveryskinstratum corneum |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonio José Guillot Ana Sara Cordeiro Ryan F. Donnelly M. Carmen Montesinos Teresa M. Garrigues Ana Melero |
spellingShingle |
Antonio José Guillot Ana Sara Cordeiro Ryan F. Donnelly M. Carmen Montesinos Teresa M. Garrigues Ana Melero Microneedle-Based Delivery: An Overview of Current Applications and Trends Pharmaceutics microneedles microneedle array transdermal delivery skin stratum corneum |
author_facet |
Antonio José Guillot Ana Sara Cordeiro Ryan F. Donnelly M. Carmen Montesinos Teresa M. Garrigues Ana Melero |
author_sort |
Antonio José Guillot |
title |
Microneedle-Based Delivery: An Overview of Current Applications and Trends |
title_short |
Microneedle-Based Delivery: An Overview of Current Applications and Trends |
title_full |
Microneedle-Based Delivery: An Overview of Current Applications and Trends |
title_fullStr |
Microneedle-Based Delivery: An Overview of Current Applications and Trends |
title_full_unstemmed |
Microneedle-Based Delivery: An Overview of Current Applications and Trends |
title_sort |
microneedle-based delivery: an overview of current applications and trends |
publisher |
MDPI AG |
series |
Pharmaceutics |
issn |
1999-4923 |
publishDate |
2020-06-01 |
description |
Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed as a minimally invasive, painless system which can bypass the <i>stratum</i> <i>corneum</i>, overcoming the potential drawbacks of subcutaneous injections and other transdermal delivery systems such as chemical enhancers, nano and microparticles, or physical treatments. As a trendy field in pharmaceutical and biomedical research, its applications are constantly evolving, even though they are based on very well-established techniques. The number of molecules administered by MNA are also increasing, with insulin and vaccines administration being the most investigated. Furthermore, MNA are being used to deliver cells and applied in other organs and tissues like the eyes and buccal mucosae. This review intends to offer a general overview of the current state of MNA research, focusing on the strategies, applications, and types of molecules delivered recently by these systems. In addition, some information about the materials and manufacturing processes is presented and safety data is discussed. |
topic |
microneedles microneedle array transdermal delivery skin stratum corneum |
url |
https://www.mdpi.com/1999-4923/12/6/569 |
work_keys_str_mv |
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