BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells
The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated. A disrupted BMP signaling pathway results in severe skeletal defects. Murine calvaria has been identified to have dual-t...
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doaj-3186cb9a9aee4a9aa281a418817d2e6d2020-11-25T01:20:47ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-03-01810.3389/fcell.2020.00135514958BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem CellsGuiqian Chen0Haodong Xu1Yifeng Yao2Tingting Xu3Mengting Yuan4Xingen Zhang5Zhengbing Lv6Mengrui Wu7Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaDepartment of Orthopedics, Zhejiang Rongjun Hospital, Jiaxing, ChinaZhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, ChinaInstitute of Genetics, Life Science College, Zhejiang University, Hangzhou, ChinaThe bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated. A disrupted BMP signaling pathway results in severe skeletal defects. Murine calvaria has been identified to have dual-tissue lineages, namely, the cranial neural-crest cells and the paraxial mesoderm. Modulations of the BMP signaling pathway have been demonstrated to be significant in determining calvarial osteogenic potentials and ossification in vitro and in vivo. More importantly, the BMP signaling pathway plays a role in the maintenance of the homeostasis of the calvarial stem cells, indicating a potential clinic significance in calvarial bone and in expediting regeneration. Following the inherent evidence of BMP signaling in craniofacial biology, we summarize recent discoveries relating to BMP signaling in the development of calvarial structures, functions of the suture stem cells and their niche and regeneration. This review will not only provide a better understanding of BMP signaling in cranial biology, but also exhibit the molecular targets of BMP signaling that possess clinical potential for tissue regeneration.https://www.frontiersin.org/article/10.3389/fcell.2020.00135/fullBMP signalingneural-crest cellssuture stem cellcalvarial regenerationmesoderm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guiqian Chen Haodong Xu Yifeng Yao Tingting Xu Mengting Yuan Xingen Zhang Zhengbing Lv Mengrui Wu |
spellingShingle |
Guiqian Chen Haodong Xu Yifeng Yao Tingting Xu Mengting Yuan Xingen Zhang Zhengbing Lv Mengrui Wu BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells Frontiers in Cell and Developmental Biology BMP signaling neural-crest cells suture stem cell calvarial regeneration mesoderm |
author_facet |
Guiqian Chen Haodong Xu Yifeng Yao Tingting Xu Mengting Yuan Xingen Zhang Zhengbing Lv Mengrui Wu |
author_sort |
Guiqian Chen |
title |
BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells |
title_short |
BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells |
title_full |
BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells |
title_fullStr |
BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells |
title_full_unstemmed |
BMP Signaling in the Development and Regeneration of Cranium Bones and Maintenance of Calvarial Stem Cells |
title_sort |
bmp signaling in the development and regeneration of cranium bones and maintenance of calvarial stem cells |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-03-01 |
description |
The bone morphogenetic protein (BMP) signaling pathway is highly conserved across many species, and its importance for the patterning of the skeletal system has been demonstrated. A disrupted BMP signaling pathway results in severe skeletal defects. Murine calvaria has been identified to have dual-tissue lineages, namely, the cranial neural-crest cells and the paraxial mesoderm. Modulations of the BMP signaling pathway have been demonstrated to be significant in determining calvarial osteogenic potentials and ossification in vitro and in vivo. More importantly, the BMP signaling pathway plays a role in the maintenance of the homeostasis of the calvarial stem cells, indicating a potential clinic significance in calvarial bone and in expediting regeneration. Following the inherent evidence of BMP signaling in craniofacial biology, we summarize recent discoveries relating to BMP signaling in the development of calvarial structures, functions of the suture stem cells and their niche and regeneration. This review will not only provide a better understanding of BMP signaling in cranial biology, but also exhibit the molecular targets of BMP signaling that possess clinical potential for tissue regeneration. |
topic |
BMP signaling neural-crest cells suture stem cell calvarial regeneration mesoderm |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00135/full |
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