BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis

Breast cancer amplified sequence 2 (BCAS2) is involved in pre-mRNA splicing but its physiological role is unclear. Here, the authors find BCAS2 enriched in mice spermatogonia in the testes, and BCAS2 deletion in germ cells alters alternative splicing of spermatogenesis-related genes, causing male in...

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Main Authors:	Wenbo Liu, Fengchao Wang, Qianhua Xu, Junchao Shi, Xiaoxin Zhang, Xukun Lu, Zhen-Ao Zhao, Zheng Gao, Huaixiao Ma, Enkui Duan, Fei Gao, Shaorong Gao, Zhaohong Yi, Lei Li
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms14182

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spelling	doaj-318f4f53fb5a48d5adc1879ed32726192021-05-11T07:14:54ZengNature Publishing GroupNature Communications2041-17232017-01-018111110.1038/ncomms14182BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosisWenbo Liu0Fengchao Wang1Qianhua Xu2Junchao Shi3Xiaoxin Zhang4Xukun Lu5Zhen-Ao Zhao6Zheng Gao7Huaixiao Ma8Enkui Duan9Fei Gao10Shaorong Gao11Zhaohong Yi12Lei Li13School of Life Sciences, University of Science and Technology of ChinaNational Institute of Biological SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesSchool of Life Sciences and Technology, Tongji UniversityKey Laboratory of Urban Agriculture (North) of Ministry of Agriculture, College of Biological Science and Engineering, Beijing University of AgricultureState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesBreast cancer amplified sequence 2 (BCAS2) is involved in pre-mRNA splicing but its physiological role is unclear. Here, the authors find BCAS2 enriched in mice spermatogonia in the testes, and BCAS2 deletion in germ cells alters alternative splicing of spermatogenesis-related genes, causing male infertility.https://doi.org/10.1038/ncomms14182
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wenbo Liu Fengchao Wang Qianhua Xu Junchao Shi Xiaoxin Zhang Xukun Lu Zhen-Ao Zhao Zheng Gao Huaixiao Ma Enkui Duan Fei Gao Shaorong Gao Zhaohong Yi Lei Li
spellingShingle	Wenbo Liu Fengchao Wang Qianhua Xu Junchao Shi Xiaoxin Zhang Xukun Lu Zhen-Ao Zhao Zheng Gao Huaixiao Ma Enkui Duan Fei Gao Shaorong Gao Zhaohong Yi Lei Li BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis Nature Communications
author_facet	Wenbo Liu Fengchao Wang Qianhua Xu Junchao Shi Xiaoxin Zhang Xukun Lu Zhen-Ao Zhao Zheng Gao Huaixiao Ma Enkui Duan Fei Gao Shaorong Gao Zhaohong Yi Lei Li
author_sort	Wenbo Liu
title	BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
title_short	BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
title_full	BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
title_fullStr	BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
title_full_unstemmed	BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis
title_sort	bcas2 is involved in alternative mrna splicing in spermatogonia and the transition to meiosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-01-01
description	Breast cancer amplified sequence 2 (BCAS2) is involved in pre-mRNA splicing but its physiological role is unclear. Here, the authors find BCAS2 enriched in mice spermatogonia in the testes, and BCAS2 deletion in germ cells alters alternative splicing of spermatogenesis-related genes, causing male infertility.
url	https://doi.org/10.1038/ncomms14182
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BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis

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