3D Powder Printed Bioglass and β-Tricalcium Phosphate Bone Scaffolds

• Main Authors: Michael Seidenstuecker, Laura Kerr, Anke Bernstein, Hermann O. Mayr, Norbert P. Suedkamp, Rainer Gadow, Peter Krieg, Sergio Hernandez Latorre, Ralf Thomann, Frank Syrowatka, Steffen Esslinger
• Format: Article
• Language: English
• Published: MDPI AG 2017-12-01
• Series: Materials
• Subjects: 3D printing; bone scaffolds; biocompatibility in vitro; bioglass; β-TCP
• Online Access: https://www.mdpi.com/1996-1944/11/1/13

The use of both bioglass (BG) and β tricalcium phosphate (β-TCP) for bone replacement applications has been studied extensively due to the materials’ high biocompatibility and ability to resorb when implanted in the body. 3D printing has been explored as a fast and versatile technique for the fabrication of porous bone scaffolds. This project investigates the effects of using different combinations of a composite BG and β-TCP powder for 3D printing of porous bone scaffolds. Porous 3D powder printed bone scaffolds of BG, β-TCP, 50/50 BG/β-TCP and 70/30 BG/β-TCP compositions were subject to a variety of characterization and biocompatibility tests. The porosity characteristics, surface roughness, mechanical strength, viability for cell proliferation, material cytotoxicity and in vitro bioactivity were assessed. The results show that the scaffolds can support osteoblast-like MG-63 cells growth both on the surface of and within the scaffold material and do not show alarming cytotoxicity; the porosity and surface characteristics of the scaffolds are appropriate. Of the two tested composite materials, the 70/30 BG/β-TCP scaffold proved to be superior in terms of biocompatibility and mechanical strength. The mechanical strength of the scaffolds makes them unsuitable for load bearing applications. However, they can be useful for other applications such as bone fillers.