Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques
Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2017-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02222-8 |
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doaj-31917530d7414bac87d6c4b747a76d292021-05-11T07:54:41ZengNature Publishing GroupNature Communications2041-17232017-12-018111110.1038/s41467-017-02222-8Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaquesDawn M. Dudley0Christina M. Newman1Joseph Lalli2Laurel M. Stewart3Michelle R. Koenig4Andrea M. Weiler5Matthew R. Semler6Gabrielle L. Barry7Katie R. Zarbock8Mariel S. Mohns9Meghan E. Breitbach10Nancy Schultz-Darken11Eric Peterson12Wendy Newton13Emma L. Mohr14Saverio Capuano III15Jorge E. Osorio16Shelby L. O’Connor17David H. O’Connor18Thomas C. Friedrich19Matthew T. Aliota20Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Wisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Department of Pediatrics, University of Wisconsin-Madison, University of Wisconsin Clinical Science Center, 600 Highland AveWisconsin National Primate Research Center, University of Wisconsin-Madison, 1220 Capitol Ct.Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, 3170 UW Medical Foundation Centennial Building, 1685 Highland Ave.Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, 1656 Linden Dr.Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity.https://doi.org/10.1038/s41467-017-02222-8 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dawn M. Dudley Christina M. Newman Joseph Lalli Laurel M. Stewart Michelle R. Koenig Andrea M. Weiler Matthew R. Semler Gabrielle L. Barry Katie R. Zarbock Mariel S. Mohns Meghan E. Breitbach Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano III Jorge E. Osorio Shelby L. O’Connor David H. O’Connor Thomas C. Friedrich Matthew T. Aliota |
| spellingShingle |
Dawn M. Dudley Christina M. Newman Joseph Lalli Laurel M. Stewart Michelle R. Koenig Andrea M. Weiler Matthew R. Semler Gabrielle L. Barry Katie R. Zarbock Mariel S. Mohns Meghan E. Breitbach Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano III Jorge E. Osorio Shelby L. O’Connor David H. O’Connor Thomas C. Friedrich Matthew T. Aliota Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques Nature Communications |
| author_facet |
Dawn M. Dudley Christina M. Newman Joseph Lalli Laurel M. Stewart Michelle R. Koenig Andrea M. Weiler Matthew R. Semler Gabrielle L. Barry Katie R. Zarbock Mariel S. Mohns Meghan E. Breitbach Nancy Schultz-Darken Eric Peterson Wendy Newton Emma L. Mohr Saverio Capuano III Jorge E. Osorio Shelby L. O’Connor David H. O’Connor Thomas C. Friedrich Matthew T. Aliota |
| author_sort |
Dawn M. Dudley |
| title |
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques |
| title_short |
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques |
| title_full |
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques |
| title_fullStr |
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques |
| title_full_unstemmed |
Infection via mosquito bite alters Zika virus tissue tropism and replication kinetics in rhesus macaques |
| title_sort |
infection via mosquito bite alters zika virus tissue tropism and replication kinetics in rhesus macaques |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-12-01 |
| description |
Vector saliva can affect infectivity and pathogenesis of vector-borne viruses, but this hasn’t been studied for Zika virus infection. Here, Dudley et al. show that mosquito-mediated Zika infection of macaques results in altered replication kinetics and greater sequence heterogeneity. |
| url |
https://doi.org/10.1038/s41467-017-02222-8 |
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