Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats
The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which r...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2015/985042 |
id |
doaj-3196dcf3f94643848859d75ec8e6bd00 |
---|---|
record_format |
Article |
spelling |
doaj-3196dcf3f94643848859d75ec8e6bd002020-11-24T23:49:41ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/985042985042Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar RatsMohd Nazri Abu0Suhana Samat1Norathirah Kamarapani2Fuzina Nor Hussein3Wan Iryani Wan Ismail4Hamzah Fansuri Hassan5Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, MalaysiaFaculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, MalaysiaFaculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, MalaysiaFaculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor, MalaysiaFaculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, MalaysiaFaculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, MalaysiaThe antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated with T. crispa (HFDTC), and the high fat diet treated with orlistat (HFDO). After sixteen weeks of treatment, blood and organs were harvested for analyses. Results showed that T. crispa significantly (p < 0.05) reduced the body weight (41.14 ± 1.40%), adiposity index serum levels (4.910 ± 0.80%), aspartate aminotransferase (AST: 161 ± 4.71 U/L), alanine aminotransferase (ALT: 100.95 ± 3.10 U/L), total cholesterol (TC: 18.55 ± 0.26 mmol/L), triglycerides (TG: 3.70 ± 0.11 mmol/L), blood glucose (8.50 ± 0.30 mmo/L), resistin (0.74 ± 0.20 ng/mL), and leptin (17.428 ± 1.50 ng/mL) hormones in HFDTC group. The insulin (1.65 ± 0.07 pg/mL) and C-peptide (136.48 pmol/L) hormones were slightly decreased but within normal range. The histological results showed unharmed and intact liver tissues in HFDTC group. As a conclusion, T. crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet.http://dx.doi.org/10.1155/2015/985042 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohd Nazri Abu Suhana Samat Norathirah Kamarapani Fuzina Nor Hussein Wan Iryani Wan Ismail Hamzah Fansuri Hassan |
spellingShingle |
Mohd Nazri Abu Suhana Samat Norathirah Kamarapani Fuzina Nor Hussein Wan Iryani Wan Ismail Hamzah Fansuri Hassan Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats Evidence-Based Complementary and Alternative Medicine |
author_facet |
Mohd Nazri Abu Suhana Samat Norathirah Kamarapani Fuzina Nor Hussein Wan Iryani Wan Ismail Hamzah Fansuri Hassan |
author_sort |
Mohd Nazri Abu |
title |
Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats |
title_short |
Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats |
title_full |
Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats |
title_fullStr |
Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats |
title_full_unstemmed |
Tinospora crispa Ameliorates Insulin Resistance Induced by High Fat Diet in Wistar Rats |
title_sort |
tinospora crispa ameliorates insulin resistance induced by high fat diet in wistar rats |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
The antidiabetic properties of Tinospora crispa, a local herb that has been used in traditional Malay medicine and rich in antioxidant, were explored based on obesity-linked insulin resistance condition. Male Wistar rats were randomly divided into four groups, namely, the normal control (NC) which received standard rodent diet, the high fat diet (HFD) which received high fat diet only, the high fat diet treated with T. crispa (HFDTC), and the high fat diet treated with orlistat (HFDO). After sixteen weeks of treatment, blood and organs were harvested for analyses. Results showed that T. crispa significantly (p < 0.05) reduced the body weight (41.14 ± 1.40%), adiposity index serum levels (4.910 ± 0.80%), aspartate aminotransferase (AST: 161 ± 4.71 U/L), alanine aminotransferase (ALT: 100.95 ± 3.10 U/L), total cholesterol (TC: 18.55 ± 0.26 mmol/L), triglycerides (TG: 3.70 ± 0.11 mmol/L), blood glucose (8.50 ± 0.30 mmo/L), resistin (0.74 ± 0.20 ng/mL), and leptin (17.428 ± 1.50 ng/mL) hormones in HFDTC group. The insulin (1.65 ± 0.07 pg/mL) and C-peptide (136.48 pmol/L) hormones were slightly decreased but within normal range. The histological results showed unharmed and intact liver tissues in HFDTC group. As a conclusion, T. crispa ameliorates insulin resistance-associated with obesity in Wistar rats fed with high fat diet. |
url |
http://dx.doi.org/10.1155/2015/985042 |
work_keys_str_mv |
AT mohdnazriabu tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats AT suhanasamat tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats AT norathirahkamarapani tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats AT fuzinanorhussein tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats AT waniryaniwanismail tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats AT hamzahfansurihassan tinosporacrispaamelioratesinsulinresistanceinducedbyhighfatdietinwistarrats |
_version_ |
1725481283545464832 |