Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal and rapidly progressing neurodegenerative disease without effective treatment. The receptor for advanced glycation end products (RAGE) and the toll-like receptor (TLR) system are major components of the innate immune system, which ha...

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Bibliographic Details
Main Authors: John D. Lee, Ning Liu, Samantha C. Levin, Lars Ottosson, Ulf Andersson, Helena E. Harris, Trent M. Woodruff
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Journal of Neuroinflammation
Subjects:
TLR4
RAGE
Neuroinflammation
Innate immune system
Online Access:http://link.springer.com/article/10.1186/s12974-019-1435-2

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