Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature
Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is c...
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doaj-31a096444e55425cbecd0520180f7cda2020-11-24T22:55:27ZengKarger PublishersCase Reports in Dermatology1662-65672017-05-01921710.1159/000475802475802Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the LiteratureAneline CasagrandaMariano SuppaFlorence DehavayVéronique del MarmolDrug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs.http://www.karger.com/Article/FullText/475802Severe cutaneous adverse reactionsDRESSStevens-Johnson syndromeRegiSCAR |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aneline Casagranda Mariano Suppa Florence Dehavay Véronique del Marmol |
spellingShingle |
Aneline Casagranda Mariano Suppa Florence Dehavay Véronique del Marmol Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature Case Reports in Dermatology Severe cutaneous adverse reactions DRESS Stevens-Johnson syndrome RegiSCAR |
author_facet |
Aneline Casagranda Mariano Suppa Florence Dehavay Véronique del Marmol |
author_sort |
Aneline Casagranda |
title |
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature |
title_short |
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature |
title_full |
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature |
title_fullStr |
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature |
title_full_unstemmed |
Overlapping DRESS and Stevens-Johnson Syndrome: Case Report and Review of the Literature |
title_sort |
overlapping dress and stevens-johnson syndrome: case report and review of the literature |
publisher |
Karger Publishers |
series |
Case Reports in Dermatology |
issn |
1662-6567 |
publishDate |
2017-05-01 |
description |
Drug-induced severe cutaneous adverse reactions (SCARs) include acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms (DRESS), and epidermal necrolysis (Stevens-Johnson syndrome [SJS], toxic epidermal necrolysis). The identification of the causal drug is crucial in order to avoid further exposure, but making the right differential diagnosis of the type of SCAR is equally important since treatment, follow-up, and prognosis of different SCARs are not the same. These syndromes are distinct entities with different clinical, biological, and histological patterns, but sometimes the early distinction between 2 SCARs can be extremely challenging, and overlapping conditions could therefore be taken into consideration, although true overlapping SCARs are very rare when using strict diagnostic criteria (described by the RegiSCAR group). Only a better understanding of the physiopathology of the SCARs could possibly explain these ambiguities and overlaps. We report a case of SCAR in an 86-year-old patient probably induced by allopurinol and simultaneously fulfilling the diagnostic criteria for DRESS and SJS, thus considered as an overlapping case of SCARs. |
topic |
Severe cutaneous adverse reactions DRESS Stevens-Johnson syndrome RegiSCAR |
url |
http://www.karger.com/Article/FullText/475802 |
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