Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy

Uveal melanoma (UM) is a primary neoplasm of the eye arising from the melanocytes residing in the iris, ciliary body or choroid. It is the most frequent intraocular malignancy and often determines metastases at distant sites, with a peculiar tropism for the liver. Metastatic UM has a poor prognosis,...

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Main Authors:	Ilaria Proietti, Nevena Skroza, Luca Filippi, Nicoletta Bernardini, Alessandra Mambrin, Ersilia Tolino, Giovanni Rossi, Anna Marchesiello, Federica Marraffa, Salvatore Volpe, Oreste Bagni, Concetta Potenza
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Life
Subjects:	uveal melanoma selective internal radiation therapy immunotherapy anti-PD1
Online Access:	https://www.mdpi.com/2075-1729/11/7/692

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spelling	doaj-31a8ed533a3e427a81d1b2b25a729fe42021-07-23T13:50:40ZengMDPI AGLife2075-17292021-07-011169269210.3390/life11070692Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 TherapyIlaria Proietti0Nevena Skroza1Luca Filippi2Nicoletta Bernardini3Alessandra Mambrin4Ersilia Tolino5Giovanni Rossi6Anna Marchesiello7Federica Marraffa8Salvatore Volpe9Oreste Bagni10Concetta Potenza11Dermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDepartment of Nuclear Medicine, “Santa Maria Goretti” Hospital, Via Antonio Canova, 04100 Latina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyDepartment of Nuclear Medicine, “Santa Maria Goretti” Hospital, Via Antonio Canova, 04100 Latina, ItalyDermatology Unit “Daniele Innocenzi”, “A. Fiorini” Hospital, Via Firenze, 1, 04019 Terracina, ItalyUveal melanoma (UM) is a primary neoplasm of the eye arising from the melanocytes residing in the iris, ciliary body or choroid. It is the most frequent intraocular malignancy and often determines metastases at distant sites, with a peculiar tropism for the liver. Metastatic UM has a poor prognosis, as any treatment affects the natural course of this fatal disease. Herein, we report a case of a UM metastatic to the liver in a 54 year-old female patient, initially treated with nivolumab without success. The patient was then scheduled for selective internal radiation therapy (SIRT) while continuing immunotherapy. This combination led to a complete and durable response and the patient is currently free of disease, two years after the diagnosis of the hepatic metastases. The association between SIRT and immunotherapy (IT) has very promising perspectives for metastatic UM, especially considering the disappointing or contradictory results of classic chemotherapies, IT alone and targeted therapies. Furthermore, this combination has been shown to have a good security profile. However, further studies are needed to confirm the efficacy of associating SIRT and IT and to clarify some unsolved problems, such as the timing of administration of these two therapies.https://www.mdpi.com/2075-1729/11/7/692uveal melanomaselective internal radiation therapyimmunotherapyanti-PD1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ilaria Proietti Nevena Skroza Luca Filippi Nicoletta Bernardini Alessandra Mambrin Ersilia Tolino Giovanni Rossi Anna Marchesiello Federica Marraffa Salvatore Volpe Oreste Bagni Concetta Potenza
spellingShingle	Ilaria Proietti Nevena Skroza Luca Filippi Nicoletta Bernardini Alessandra Mambrin Ersilia Tolino Giovanni Rossi Anna Marchesiello Federica Marraffa Salvatore Volpe Oreste Bagni Concetta Potenza Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy Life uveal melanoma selective internal radiation therapy immunotherapy anti-PD1
author_facet	Ilaria Proietti Nevena Skroza Luca Filippi Nicoletta Bernardini Alessandra Mambrin Ersilia Tolino Giovanni Rossi Anna Marchesiello Federica Marraffa Salvatore Volpe Oreste Bagni Concetta Potenza
author_sort	Ilaria Proietti
title	Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy
title_short	Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy
title_full	Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy
title_fullStr	Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy
title_full_unstemmed	Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy
title_sort	long-term maintained response to selective internal radiation therapy in an oligometastatic uveal melanoma patient treated with concomitant anti-pd-1 therapy
publisher	MDPI AG
series	Life
issn	2075-1729
publishDate	2021-07-01
description	Uveal melanoma (UM) is a primary neoplasm of the eye arising from the melanocytes residing in the iris, ciliary body or choroid. It is the most frequent intraocular malignancy and often determines metastases at distant sites, with a peculiar tropism for the liver. Metastatic UM has a poor prognosis, as any treatment affects the natural course of this fatal disease. Herein, we report a case of a UM metastatic to the liver in a 54 year-old female patient, initially treated with nivolumab without success. The patient was then scheduled for selective internal radiation therapy (SIRT) while continuing immunotherapy. This combination led to a complete and durable response and the patient is currently free of disease, two years after the diagnosis of the hepatic metastases. The association between SIRT and immunotherapy (IT) has very promising perspectives for metastatic UM, especially considering the disappointing or contradictory results of classic chemotherapies, IT alone and targeted therapies. Furthermore, this combination has been shown to have a good security profile. However, further studies are needed to confirm the efficacy of associating SIRT and IT and to clarify some unsolved problems, such as the timing of administration of these two therapies.
topic	uveal melanoma selective internal radiation therapy immunotherapy anti-PD1
url	https://www.mdpi.com/2075-1729/11/7/692
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Long-Term Maintained Response to Selective Internal Radiation Therapy in an Oligometastatic Uveal Melanoma Patient Treated with Concomitant Anti-PD-1 Therapy

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