Advances in Mechanism of LincRNA-p21 in Cancer

Advances in Mechanism of LincRNA-p21 in Cancer

Long noncoding RNAs, which lack protein-coding capacity, regulate various biological processes through diverse molecular mechanisms. lincRNA-p21 is a tumor suppressor gene and related to p53. lincRNA-p21 regulates p53 through MDM2, ING1b, p21 and other targets, to participate in the regulation of ce...

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Main Authors: ZHAO Suyue, ZHU Kexiang, LI Wenjun, LI Xun
Format: Article
Language:zho
Published: Magazine House of Cancer Research on Prevention and Treatment 2020-10-01
Series:Zhongliu Fangzhi Yanjiu
Subjects:
lincrna-p21
p53
cancer
Online Access:http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0064.htm
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spelling doaj-31ad6500f74c45f98471b4d0cd59a9482020-11-25T03:52:18ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782020-10-01471080280610.3971/j.issn.1000-8578.2020.20.00648578.2020.20.0064Advances in Mechanism of LincRNA-p21 in CancerZHAO Suyue0ZHU Kexiang1LI Wenjun2LI Xun3The First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou 730000, ChinaLong noncoding RNAs, which lack protein-coding capacity, regulate various biological processes through diverse molecular mechanisms. lincRNA-p21 is a tumor suppressor gene and related to p53. lincRNA-p21 regulates p53 through MDM2, ING1b, p21 and other targets, to participate in the regulation of cell cycle, proliferation and apoptosis. lincRNA-p21 coordinates the Warburg effect through HIF-1α and participates in various biological functions. lincRNA-p21 is closely related to the prognosis and treatment of tumors. Therefore, lincRNA-p21 can be used as a biomarker for cancer diagnosis and prognosis. This paper reviews the recent progress in biological function of lincRNA-p21 and its mechanism in diseases.http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0064.htmlincrna-p21p53cancer
collection DOAJ
language zho
format Article
sources DOAJ
author ZHAO Suyue
ZHU Kexiang
LI Wenjun
LI Xun
spellingShingle ZHAO Suyue
ZHU Kexiang
LI Wenjun
LI Xun
Advances in Mechanism of LincRNA-p21 in Cancer
Zhongliu Fangzhi Yanjiu
lincrna-p21
p53
cancer
author_facet ZHAO Suyue
ZHU Kexiang
LI Wenjun
LI Xun
author_sort ZHAO Suyue
title Advances in Mechanism of LincRNA-p21 in Cancer
title_short Advances in Mechanism of LincRNA-p21 in Cancer
title_full Advances in Mechanism of LincRNA-p21 in Cancer
title_fullStr Advances in Mechanism of LincRNA-p21 in Cancer
title_full_unstemmed Advances in Mechanism of LincRNA-p21 in Cancer
title_sort advances in mechanism of lincrna-p21 in cancer
publisher Magazine House of Cancer Research on Prevention and Treatment
series Zhongliu Fangzhi Yanjiu
issn 1000-8578
1000-8578
publishDate 2020-10-01
description Long noncoding RNAs, which lack protein-coding capacity, regulate various biological processes through diverse molecular mechanisms. lincRNA-p21 is a tumor suppressor gene and related to p53. lincRNA-p21 regulates p53 through MDM2, ING1b, p21 and other targets, to participate in the regulation of cell cycle, proliferation and apoptosis. lincRNA-p21 coordinates the Warburg effect through HIF-1α and participates in various biological functions. lincRNA-p21 is closely related to the prognosis and treatment of tumors. Therefore, lincRNA-p21 can be used as a biomarker for cancer diagnosis and prognosis. This paper reviews the recent progress in biological function of lincRNA-p21 and its mechanism in diseases.
topic lincrna-p21
p53
cancer
url http://html.rhhz.net/ZLFZYJ/html/8578.2020.20.0064.htm
work_keys_str_mv AT zhaosuyue advancesinmechanismoflincrnap21incancer
AT zhukexiang advancesinmechanismoflincrnap21incancer
AT liwenjun advancesinmechanismoflincrnap21incancer
AT lixun advancesinmechanismoflincrnap21incancer
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